| The subthalamic nucleus has neurofibrillary tangles in argyrophilic grain disease and advanced Alzheimer's disease. | |
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MedLine Citation:
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PMID: 11849769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neurofibrillary tangles (NFT) are present in the subthalamic nucleus (STN) of progressive supranuclear palsy and corticobasal degeneration, two sporadic tauopathies with preferential accumulation of tau with four repeats in the microtubule binding domain (4R tau). Since recent evidence suggests that argyrophilic grain disease (AGD) is also a 4R tauopathy, we hypothesized that the STN may also be affected in AGD. Tau immunostaining was used to evaluate NFT in the STN in 18 cases of AGD compared with 18 non-AGD cases matched for age, sex and Braak stage. AGD cases had significantly more NFT in the STN than non-AGD cases (P=0.008) with no relationship between NFT score and Braak stage. Surprisingly, NFT were also found in the STN of some non-AGD cases, notably in cases with advanced Braak stage (i.e. Alzheimer's disease). When AGD and non-AGD were considered as a whole there was a correlation between neurofibrillary degeneration in the STN and Braak stage. This study demonstrates that neurofibrillary degeneration is frequent in the STN in AGD, but also detected in non-AGD cases with advanced Braak stage. |
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Authors:
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Petri Mattila; Takashi Togo; Dennis W Dickson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neuroscience letters Volume: 320 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 2002 Mar |
Date Detail:
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Created Date: 2002-02-18 Completed Date: 2002-04-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 81-5 Citation Subset: IM |
Affiliation:
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Department of Pathology, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Alzheimer Disease / pathology*, physiopathology Disease Progression Female Humans Immunohistochemistry Male Middle Aged Neurofibrillary Tangles / pathology* Neurons / pathology* Silver Staining Subthalamic Nucleus / pathology*, physiopathology tau Proteins / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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AG03949/AG/NIA NIH HHS; AG14449/AG/NIA NIH HHS; AG16574/AG/NIA NIH HHS; AG17216/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/tau Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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