Document Detail


The subthalamic nucleus has neurofibrillary tangles in argyrophilic grain disease and advanced Alzheimer's disease.
MedLine Citation:
PMID:  11849769     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neurofibrillary tangles (NFT) are present in the subthalamic nucleus (STN) of progressive supranuclear palsy and corticobasal degeneration, two sporadic tauopathies with preferential accumulation of tau with four repeats in the microtubule binding domain (4R tau). Since recent evidence suggests that argyrophilic grain disease (AGD) is also a 4R tauopathy, we hypothesized that the STN may also be affected in AGD. Tau immunostaining was used to evaluate NFT in the STN in 18 cases of AGD compared with 18 non-AGD cases matched for age, sex and Braak stage. AGD cases had significantly more NFT in the STN than non-AGD cases (P=0.008) with no relationship between NFT score and Braak stage. Surprisingly, NFT were also found in the STN of some non-AGD cases, notably in cases with advanced Braak stage (i.e. Alzheimer's disease). When AGD and non-AGD were considered as a whole there was a correlation between neurofibrillary degeneration in the STN and Braak stage. This study demonstrates that neurofibrillary degeneration is frequent in the STN in AGD, but also detected in non-AGD cases with advanced Braak stage.
Authors:
Petri Mattila; Takashi Togo; Dennis W Dickson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroscience letters     Volume:  320     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-02-18     Completed Date:  2002-04-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  81-5     Citation Subset:  IM    
Affiliation:
Department of Pathology, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Alzheimer Disease / pathology*,  physiopathology
Disease Progression
Female
Humans
Immunohistochemistry
Male
Middle Aged
Neurofibrillary Tangles / pathology*
Neurons / pathology*
Silver Staining
Subthalamic Nucleus / pathology*,  physiopathology
tau Proteins / metabolism*
Grant Support
ID/Acronym/Agency:
AG03949/AG/NIA NIH HHS; AG14449/AG/NIA NIH HHS; AG16574/AG/NIA NIH HHS; AG17216/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/tau Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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