Document Detail

A subterminal satellite located adjacent to telomeres in chimpanzees is absent from the human genome.
MedLine Citation:
PMID:  8136835     Owner:  NLM     Status:  MEDLINE    
One of the significant unresolved differences between the karyotypes of humans and African apes is the presence of positively staining G-bands at the ends of many chromosome arms in the chimpanzee and gorilla but absent from human chromosomes. Using a telomere anchored PCR strategy, we have isolated DNA from a subterminal satellite, composed of a 32 basepair A-T rich repeat, from the chimpanzee genome that hybridizes to all the additional terminal bands and at two interstitial sites. The satellite is more abundant in gorillas and is not detected in humans or orangutans. Furthermore, there is no similarity between other chimpanzee telomere-junction clones and human subterminal sequences, and therefore the organization of sequences adjacent to telomeres is very different between these closely related primates.
N J Royle; D M Baird; A J Jeffreys
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nature genetics     Volume:  6     ISSN:  1061-4036     ISO Abbreviation:  Nat. Genet.     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-04-25     Completed Date:  1994-04-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9216904     Medline TA:  Nat Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  52-6     Citation Subset:  IM    
Department of Genetics, University of Leicester, United Kingdom.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/X74280;  X74281;  X74282;  X74283
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MeSH Terms
Base Sequence
Cloning, Molecular
DNA Primers / genetics
DNA, Satellite / genetics*
Genome, Human*
Gorilla gorilla / genetics
In Situ Hybridization, Fluorescence
Molecular Sequence Data
Pan troglodytes / genetics*
Polymerase Chain Reaction
Pongo pygmaeus / genetics
Repetitive Sequences, Nucleic Acid
Sequence Homology, Nucleic Acid
Species Specificity
Reg. No./Substance:
0/DNA Primers; 0/DNA, Satellite

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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