Document Detail


A substructure approach toward polymeric receptors targeting dihydrofolate reductase inhibitors. 2. Molecularly imprinted polymers against Z-l-glutamic acid showing affinity for larger molecules.
MedLine Citation:
PMID:  14604396     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The preparation of a molecularly imprinted polymer against N-Z-L-glutamic acid using a novel bis-urea functional monomer is described. The polymer exhibits affinity for the template over N-Z-protected aspartic acid and glycine and, further, is capable of binding larger molecules, e.g., the anti-cancer drug methotrexate, containing the glutamate substructure.
Authors:
Andrew J Hall; Laura Achilli; Panagiotis Manesiotis; Milena Quaglia; Ersilia De Lorenzi; Börje Sellergren
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of organic chemistry     Volume:  68     ISSN:  0022-3263     ISO Abbreviation:  J. Org. Chem.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-07     Completed Date:  2004-03-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985193R     Medline TA:  J Org Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  9132-5     Citation Subset:  IM    
Affiliation:
Institut für Anorganische Chemie und Analytische Chemie, Johannes Gutenberg Universität, Duesbergweg 10-14, D-55099, Mainz, Germany. andy@infu.uni-dortmund.de
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MeSH Terms
Descriptor/Qualifier:
Enzyme Inhibitors / chemistry*
Folic Acid Antagonists / chemistry*,  pharmacology
Glutamic Acid / chemistry*
Magnetic Resonance Spectroscopy
Methotrexate / chemistry*,  pharmacology
Polymers / chemistry*
Tetrahydrofolate Dehydrogenase / drug effects*
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Folic Acid Antagonists; 0/Polymers; 56-86-0/Glutamic Acid; 59-05-2/Methotrexate; EC 1.5.1.3/Tetrahydrofolate Dehydrogenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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