| A substructure approach toward polymeric receptors targeting dihydrofolate reductase inhibitors. 2. Molecularly imprinted polymers against Z-l-glutamic acid showing affinity for larger molecules. | |
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MedLine Citation:
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PMID: 14604396 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The preparation of a molecularly imprinted polymer against N-Z-L-glutamic acid using a novel bis-urea functional monomer is described. The polymer exhibits affinity for the template over N-Z-protected aspartic acid and glycine and, further, is capable of binding larger molecules, e.g., the anti-cancer drug methotrexate, containing the glutamate substructure. |
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Authors:
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Andrew J Hall; Laura Achilli; Panagiotis Manesiotis; Milena Quaglia; Ersilia De Lorenzi; Börje Sellergren |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of organic chemistry Volume: 68 ISSN: 0022-3263 ISO Abbreviation: J. Org. Chem. Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-11-07 Completed Date: 2004-03-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985193R Medline TA: J Org Chem Country: United States |
Other Details:
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Languages: eng Pagination: 9132-5 Citation Subset: IM |
Affiliation:
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Institut für Anorganische Chemie und Analytische Chemie, Johannes Gutenberg Universität, Duesbergweg 10-14, D-55099, Mainz, Germany. andy@infu.uni-dortmund.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Enzyme Inhibitors
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chemistry* Folic Acid Antagonists / chemistry*, pharmacology Glutamic Acid / chemistry* Magnetic Resonance Spectroscopy Methotrexate / chemistry*, pharmacology Polymers / chemistry* Tetrahydrofolate Dehydrogenase / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Folic Acid Antagonists; 0/Polymers; 56-86-0/Glutamic Acid; 59-05-2/Methotrexate; EC 1.5.1.3/Tetrahydrofolate Dehydrogenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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