Document Detail


A subset of dorsal neurons modulates circadian behavior and light responses in Drosophila.
MedLine Citation:
PMID:  17329209     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A fundamental property of circadian rhythms is their ability to persist under constant conditions. In Drosophila, the ventral Lateral Neurons (LNvs) are the pacemaker neurons driving circadian behavior under constant darkness. Wild-type flies are arrhythmic under constant illumination, but flies defective for the circadian photoreceptor CRY remain rhythmic. We found that flies overexpressing the pacemaker gene per or the morgue gene are also behaviorally rhythmic under constant light. Unexpectedly, the LNvs do not drive these rhythms: they are molecularly arrhythmic, and PDF--the neuropeptide they secrete to synchronize behavioral rhythms under constant darkness--is dispensable for rhythmicity in constant light. Molecular circadian rhythms are only found in a group of Dorsal Neurons: the DN1s. Thus, a subset of Dorsal Neurons shares with the LNvs the ability to function as pacemakers for circadian behavior, and its importance is promoted by light.
Authors:
Alejandro Murad; Myai Emery-Le; Patrick Emery
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Neuron     Volume:  53     ISSN:  0896-6273     ISO Abbreviation:  Neuron     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-01     Completed Date:  2007-04-12     Revised Date:  2014-09-16    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  689-701     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Genetically Modified
Circadian Rhythm / physiology*
Cryptochromes
Darkness
Drosophila / physiology*
Drosophila Proteins / genetics*,  physiology
Eye Proteins / genetics,  physiology
Lighting
Neurons / physiology*
Neuropeptides / genetics,  physiology
Nuclear Proteins / genetics,  physiology
Period Circadian Proteins
Receptors, G-Protein-Coupled / genetics,  physiology
Grant Support
ID/Acronym/Agency:
5R01GM066777/GM/NIGMS NIH HHS; R01 GM066777/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Cryptochromes; 0/Drosophila Proteins; 0/Eye Proteins; 0/Neuropeptides; 0/Nuclear Proteins; 0/PER protein, Drosophila; 0/Period Circadian Proteins; 0/Receptors, G-Protein-Coupled; 0/cryptochrome protein, Drosophila; 0/morgue protein, Drosophila; 0/pdf protein, Drosophila; 0/timeless protein, Drosophila
Comments/Corrections
Comment In:
Neuron. 2007 Mar 1;53(5):621-3   [PMID:  17329201 ]

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