Document Detail


A subpopulation of CD133(+) cancer stem-like cells characterized in human oral squamous cell carcinoma confer resistance to chemotherapy.
MedLine Citation:
PMID:  19748175     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The potential role of cancer stem-like cells (CSCs) in chemoresistance of human oral squamous cell carcinoma (OSCC) was examined. A small subpopulation (1-2%) of CD133(+) CSCs was identified in OSCC cell lines and tissues. These CD133(+) CSCs possess higher clonogenicity, invasiveness, and increased in vivo tumorigenicity as compared to CD133(-) counterparts. Meanwhile, CD133(+) CSCs were substantially resistant to standard chemotherapy, wherein both in vitro and in vivo treatment with paclitaxel resulted in a marked enrichment for CD133(+) CSCs. Our data suggest that CD133(+) cells represent a small subpopulation of CSCs that may contribute to chemoresistance in human OSCC.
Authors:
Qunzhou Zhang; Shihong Shi; Yun Yen; Jimmy Brown; Joseph Quoc Ta; Anh D Le
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-09-11
Journal Detail:
Title:  Cancer letters     Volume:  289     ISSN:  1872-7980     ISO Abbreviation:  Cancer Lett.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-26     Completed Date:  2010-04-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  151-60     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Center for Craniofacial Molecular Biology, University of Southern California, School of Dentistry, Los Angeles, CA 90033, USA. qunzhouz@usc.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, CD / metabolism*
Antineoplastic Agents / adverse effects*
Carcinoma, Squamous Cell / drug therapy,  pathology*
Colony-Forming Units Assay
Drug Resistance, Neoplasm*
Female
Flow Cytometry
Glycoproteins / metabolism*
Humans
Immunoenzyme Techniques
Mice
Mice, Nude
Mouth Neoplasms / drug therapy,  pathology*
Neoplastic Stem Cells / metabolism,  pathology*
Peptides / metabolism*
RNA, Messenger / genetics,  metabolism
Reverse Transcriptase Polymerase Chain Reaction
Grant Support
ID/Acronym/Agency:
AR47359/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/AC133 antigen; 0/Antigens, CD; 0/Antineoplastic Agents; 0/Glycoproteins; 0/Peptides; 0/RNA, Messenger

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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