Document Detail

The submicrosomal distribution in rat and boar testis of some enzymes involved in androgen and 16-androstene biosynthesis.
MedLine Citation:
PMID:  884155     Owner:  NLM     Status:  MEDLINE    
The submicrosomal localization of enzymes involved in androgen and 16-androstene biosynthesis in rat and boar testis tissue has been studied. 16-androstene production was not evident in the rat testis but two enzymes concerned with androgen generation (17 alpha-hydroxy C21 steroid C-17,20 lyase; 17 beta-hydroxysteroid dehydrogenase, were found predominantly in agranular microsomes. In the boar testis the C-17,10 lyase had a similar distribution to the rat enzyme but the 17 beta-hydroxysteroid dehydrogenase was found to be evenly distributed between the two microsomal types. The enzyme system, "andien-betha synthetase", involved in the conversion of pregnenolone to 5,16-androstadien-3 beta-ol, was found mainly (66%) in the agranular microsomes but had a lower specific activity than those of the two enzymes of androgen biosynthesis that have been studied.
G M Cooke; D B Gower
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  498     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1977 Jul 
Date Detail:
Created Date:  1977-09-22     Completed Date:  1977-09-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  265-71     Citation Subset:  IM    
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MeSH Terms
Androgens / biosynthesis*
Androstenes / biosynthesis*
Hydroxysteroid Dehydrogenases / metabolism*
Lyases / metabolism*
Microscopy, Electron
Microsomes / enzymology*,  ultrastructure
Oxidoreductases / metabolism*
Testis / enzymology*
Reg. No./Substance:
0/Androgens; 0/Androstenes; 0/Hydroxysteroids; EC 1.-/Oxidoreductases; EC 1.1.-/Hydroxysteroid Dehydrogenases; EC 4.-/Lyases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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