Document Detail


A submicron emulsion as ocular vehicle for delta-8-tetrahydrocannabinol: effect on intraocular pressure in rabbits.
MedLine Citation:
PMID:  1328979     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
delta 8-Tetrahydrocannabinol (delta 8-THC), a known antiglaucoma lipophilic drug, was incorporated in a submicron emulsion for ocular administration. The mean droplet size of the emulsion was 130 +/- 41 nm, and no droplet was larger than 400 nm. No change in pH, particle size distribution or zeta potential was noted after sterilization by steam autoclaving or long-term storage over 9 months. An intense and long-lasting intraocular pressure (IOP)-depressant effect was observed after ocular application (50 microliters) of the THC emulsion, 0.4% (w/w), to rabbits with ocular hypertension (chymotrypsin model). Lesser effects were observed in normotensive rabbits. No irritation effect of either the emulsion vehicle or THC emulsion on the rabbit eyes was detected. These results underline the promising properties of submicron emulsions as vehicles for lipophilic ophthalmic drugs. The mechanism by which the emulsion induced the marked delta 8-THC antiglaucoma effect remains unclear. However, the possible involvement of delta 8-THC systemic absorption in the hypotensive effect induced by the emulsion cannot be excluded and will be the subject of further investigation.
Authors:
S Muchtar; S Almog; M T Torracca; M F Saettone; S Benita
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ophthalmic research     Volume:  24     ISSN:  0030-3747     ISO Abbreviation:  Ophthalmic Res.     Publication Date:  1992  
Date Detail:
Created Date:  1992-11-20     Completed Date:  1992-11-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0267442     Medline TA:  Ophthalmic Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  142-9     Citation Subset:  IM    
Affiliation:
Pharmacy Department, School of Pharmacy, Hebrew University of Jerusalem, Israel.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chymotrypsin
Drug Carriers
Drug Stability
Emulsions
Hydrogen-Ion Concentration
Intraocular Pressure / drug effects*
Ocular Hypertension / chemically induced,  drug therapy
Rabbits
Sterilization
Tetrahydrocannabinol / analogs & derivatives*,  chemistry,  pharmacology
Chemical
Reg. No./Substance:
0/Drug Carriers; 0/Emulsions; 1972-08-3/Tetrahydrocannabinol; 5957-75-5/delta-8-tetrahydrocannabinol; EC 3.4.21.1/Chymotrypsin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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