| The "endorphin story": a subjective account. | |
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MedLine Citation:
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PMID: 11686087 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The contribution of the researchers of IDR to some early discoveries on endorphins is recounted. Exact determination of the amino acid sequence of beta-lipotropin, discovery of the analgesic action of beta-endorphin in rats, demonstration of the partial cross-tolerance between morphine and beta-endorphin, description of the elevation of the pain threshold upon inhibition of the enzymatic breakdown of endogenous opioids by bacitracin, demonstration of inhibition of opiate tolerance and dependence by alpha-MSH and Met-enkephalin, development of the second strongest enkephalin analogue, D-Met2,Pro5-enkephalinamide, recognition of some factors conferring analgesic activity to synthetic enkephalin analogues, etc. prove that IDR has played an active role in the early history of endorphin research. |
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Authors:
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J I Székely |
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Publication Detail:
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Type: Historical Article; Journal Article |
Journal Detail:
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Title: Die Pharmazie Volume: 56 Suppl 1 ISSN: 0031-7144 ISO Abbreviation: Pharmazie Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-10-31 Completed Date: 2001-12-04 Revised Date: 2007-01-29 |
Medline Journal Info:
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Nlm Unique ID: 9800766 Medline TA: Pharmazie Country: Germany |
Other Details:
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Languages: eng Pagination: S22-30 Citation Subset: IM |
Affiliation:
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Institute for Drug Research, Budapest, Hungary. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Endorphins / chemistry, history*, pharmacology History, 20th Century Humans Hungary Pharmacology / history* |
| Chemical | |
Reg. No./Substance:
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0/Endorphins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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