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The subcortical auditory structures in the mongolian gerbil: II. Frequency-related topography of the connections with cortical field AI.
MedLine Citation:
PMID:  23408290     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We investigated the frequency-related topography of connections of the primary auditory cortical field (AI) in the Mongolian gerbil with subcortical structures of the auditory system by means of the axonal transport of two bidirectional tracers, which were simultaneoulsy injected into regions of AI with different best frequencies (BFs). We found topographic, most likely frequency-matched (tonotopic) connections as well as non-topographic (non-tonotopic) connections. AI projects in a tonotopic way to the ipsilateral ventral (MGv) and dorsal divisions (MGd) of the medial geniculate body (MGB), reticular thalamic nucleus and dorsal nucleus of the lateral lemniscus as well as to the ipsi- and contralateral dorsal cortex of the inferior colliculus (IC) and central nucleus of the IC. AI receives tonotopic inputs from MGv and MGd. Projections from different BF regions of AI terminate in a non-tonotopic way in the ipsilateral medial division of the MGB (MGm), suprageniculate thalamic nucleus (SG) and brachium of the IC (bic) as well as in the ipsi- and contralateral external cortex and pericollicular areas of the IC. The anterograde labeling in the intermediate and ventral nucleus of the lateral lemniscus, parts of the superior olivary complex and divisions of the cochlear nucleus was generally sparse, thus a clear topographic arrangement of the labeled axons could not be ruled out. AI receives non-tonotopic inputs from the ipsilateral MGm, SG and bic. In conclusion, the tonotopic and non-tonotopic corticofugal connections of AI can potentially serve for both, conservation and integration of frequency-specific information in the respective target structures. J. Comp. Neurol., 2013. © 2013 Wiley Periodicals, Inc.
Authors:
Eike Budinger; Michael Brosch; Henning Scheich; Judith Mylius
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-14
Journal Detail:
Title:  The Journal of comparative neurology     Volume:  -     ISSN:  1096-9861     ISO Abbreviation:  J. Comp. Neurol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0406041     Medline TA:  J Comp Neurol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Wiley Periodicals, Inc.
Affiliation:
Department Auditory Learning and Speech 6, D-39118 Magdeburg, Germany; Center for Behavioral Brain Sciences Magdeburg, Germany; Clinic of Neurology II, Otto-von-Guericke-University Magdeburg Leipziger Str. 44, D-39120 Magdeburg, Germany. budinger@lin-magdeburg.de.
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