Document Detail


The subcellular localisation and the time course of bismuth in the gastric mucosa of rats after short-term administration of colloidal bismuth subcitrate.
MedLine Citation:
PMID:  9522974     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to investigate if colloidal bismuth subcitrate (CBS) can penetrate the gastric mucus barrier to reach the different sites of the antral mucosa and to estimate the time course for CBS to reach and remain in the mucosa. A single dose of CBS was administered orally to rats that were sacrificed at different time intervals post treatment. The control group received gum acacia without CBS. Colloidal bismuth subcitrate, visualised as electron dense precipitate (EDP), was seen in the gastric mucus layer, intercellular spaces and intracellularly after 30 minutes and disappeared after 6 hours. Scant amounts of EDP were observed in the gastric crypts, confined only to the upper parts of these structures. We concluded that CBS can penetrate the mucus and has a wide but uneven distribution in the gastric mucosa. Colloidal bismuth subcitrate, in the concentration given only penetrated the upper two-thirds of gastric pits and not the lower one-third. We also concluded that CBS has to be given 6 hourly to ensure its continuous presence in the gastric mucosa.
Authors:
N M Ismail; M S Mustapha; R Megat
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of the Academy of Medicine, Singapore     Volume:  26     ISSN:  0304-4602     ISO Abbreviation:  Ann. Acad. Med. Singap.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-05-07     Completed Date:  1998-05-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503289     Medline TA:  Ann Acad Med Singapore     Country:  SINGAPORE    
Other Details:
Languages:  eng     Pagination:  754-7     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Faculty of Medicine, University Kebangsaan Malaysia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Infective Agents / administration & dosage,  pharmacokinetics*
Gastric Mucosa / metabolism*
Gum Arabic / pharmacokinetics
Male
Microscopy, Electron
Organometallic Compounds / administration & dosage,  pharmacokinetics*
Rats
Rats, Wistar
Time Factors
Chemical
Reg. No./Substance:
0/Anti-Infective Agents; 0/Organometallic Compounds; 57644-54-9/bismuth tripotassium dicitrate; 9000-01-5/Gum Arabic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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