Document Detail

The subcellular basis of damage to the human urinary bladder induced by irradiation.
MedLine Citation:
PMID:  6737117     Owner:  NLM     Status:  MEDLINE    
The effects of x-irradiation on the subcellular structure of the human urinary bladder were investigated by electron microscopic examination of biopsies taken during check cystoscopies from 25 patients between 1 month and 22 years after completion of a course of therapeutic radiation. All tissues of the bladder wall were damaged to some extent by the treatment. In the urothelium this was reflected by the development of more than the usual numbers of lysosomes and autophagic vacuoles in all cell layers. In the bladder wall, large often binucleate or multinucleate fibroblasts were prominent and persistent in all specimens and were associated with the development of progressive fibrosis. The vasculature and the muscle coats of the bladder wall were also damaged. In the blood vessels many endothelial cells were oedematous or necrotic and some intravascular coagulation was also observed. Smooth muscle cells became oedematous soon after irradiation, and after longer time intervals there was focal death and loss of individual muscle cells. The observed degeneration and extensive necrosis of the bladder wall, which involved severe destruction and disorganization of the muscular layers, is sufficient to explain the clinical sequelae of bladder irradiation, namely loss of elasticity, reduced capacity and incomplete micturition with residual urine.
G N Antonakopoulos; R M Hicks; R J Berry
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pathology     Volume:  143     ISSN:  0022-3417     ISO Abbreviation:  J. Pathol.     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1984-08-13     Completed Date:  1984-08-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0204634     Medline TA:  J Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  103-16     Citation Subset:  IM    
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MeSH Terms
Blood Vessels / radiation effects,  ultrastructure
Connective Tissue / radiation effects
Epithelium / radiation effects,  ultrastructure
Microscopy, Electron
Middle Aged
Muscle, Smooth / radiation effects,  ultrastructure
Nerve Tissue / radiation effects
Radiation Injuries / pathology*
Radiotherapy / adverse effects*
Urinary Bladder / blood supply,  radiation effects*,  ultrastructure

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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