Document Detail

A study on withdrawal related haemodynamic response in chronic propranolol treated conscious rats.
MedLine Citation:
PMID:  8276504     Owner:  NLM     Status:  MEDLINE    
Single dose of propranolol hydrochloride (5 mg/kg, i.p.) caused significant fall in heart rate (HR) but not in systolic blood pressure (SBP) in normotensive conscious rats. Multiple doses of propranolol (5 mg/kg, i.p., twice-a-day for 5 wk) caused significant fall in both HR and SBP at 2 wk and 4 wk in normotensive conscious rats. Sudden withdrawal of propranolol at 5 wk caused a significant blood pressure upswing and tachycardia between 12-24 h followed by normalization of both blood pressure and heart rate. The study documents a possible model of rebound hypertension in normotensive conscious rats.
A Chakrabarti; P L Sharma
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of physiology and pharmacology     Volume:  37     ISSN:  0019-5499     ISO Abbreviation:  Indian J. Physiol. Pharmacol.     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1994-02-07     Completed Date:  1994-02-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0374707     Medline TA:  Indian J Physiol Pharmacol     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  235-7     Citation Subset:  IM    
Department of Pharmacology, Postgraduate Institute of Medical Education & Research, Chandigarh.
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MeSH Terms
Blood Pressure / drug effects
Heart Rate / drug effects
Hypertension / chemically induced*
Propranolol / adverse effects*
Rats, Wistar
Substance Withdrawal Syndrome / physiopathology*
Tachycardia / chemically induced*
Reg. No./Substance:

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