Document Detail


A study on withdrawal related haemodynamic response in chronic propranolol treated conscious rats.
MedLine Citation:
PMID:  8276504     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Single dose of propranolol hydrochloride (5 mg/kg, i.p.) caused significant fall in heart rate (HR) but not in systolic blood pressure (SBP) in normotensive conscious rats. Multiple doses of propranolol (5 mg/kg, i.p., twice-a-day for 5 wk) caused significant fall in both HR and SBP at 2 wk and 4 wk in normotensive conscious rats. Sudden withdrawal of propranolol at 5 wk caused a significant blood pressure upswing and tachycardia between 12-24 h followed by normalization of both blood pressure and heart rate. The study documents a possible model of rebound hypertension in normotensive conscious rats.
Authors:
A Chakrabarti; P L Sharma
Related Documents :
21199174 - High-resolution esophageal pressure topography is superior to conventional sleeve manom...
9166664 - Islet capillary blood pressure increase mediated by hyperglycemia in niddm gk rats.
6717244 - A hypertensive substance found in the blood of spontaneously hypertensive rats.
25314664 - "endoflip(®) evaluation of pharyngo-oesophageal segment tone and swallowing in a clinic...
6842634 - Effect of hemorrhage and anoxia on hepatic gluconeogenesis and potassium balance in the...
842374 - Time course and extent of carotid sinus baroreceptor threshold resetting in rats with r...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of physiology and pharmacology     Volume:  37     ISSN:  0019-5499     ISO Abbreviation:  Indian J. Physiol. Pharmacol.     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1994-02-07     Completed Date:  1994-02-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0374707     Medline TA:  Indian J Physiol Pharmacol     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  235-7     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Postgraduate Institute of Medical Education & Research, Chandigarh.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Heart Rate / drug effects
Hypertension / chemically induced*
Male
Propranolol / adverse effects*
Rats
Rats, Wistar
Substance Withdrawal Syndrome / physiopathology*
Tachycardia / chemically induced*
Chemical
Reg. No./Substance:
525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Unwanted effects of ciprofloxacin in Indian population.
Next Document:  Modification of tricyclic antidepressant analgesia by calcium channel blockers.