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A study of venous thrombosis incidence in patients with acute hyperthyroidism.
MedLine Citation:
PMID:  22758384     Owner:  NLM     Status:  Publisher    
Background:  Hyperthyroidism is not a widely acknowledged risk factor for venous thrombosis, such as deep vein thrombosis, pulmonary embolism and cerebral venous thrombosis. Several case reports and case-control studies support an association between venous thrombosis and hyperthyroidism. Prothrombotic changes in the coagulation pathway in thyrotoxic subjects include reversible elevation of factor VIII and Von Willebrands factor, and give biological plausibility to the association and possibly causation for venous thrombosis. Aim:  We sought to determine the incidence of symptomatic venous thrombosis in acute hyperthyroidism. Methods:  A retrospective review of consecutive outpatients presenting to the endocrinology clinic at our district hospitals from January 2006 to December 2008 with acute hyperthyroidism was carried out. All occurrences of objectively proven symptomatic venous thrombosis (deep vein thrombosis, pulmonary embolism and cerebral vein thrombosis) in he 6 months following the diagnosis of hyperthyroidism were sought. Results:  Four hundred and twenty eight patients were identified of whom most were female (80%) and relatively young (mean age 47 years). Three patients (0.70%: 95% CI 0.14-2.0%) were identified with a confirmed venous thrombosis within 6 months of the diagnosis of hyperthyroidism. Conclusions:  Although the literature suggests moderate association between VT and acute hyperthyroidism our data shows that the absolute risk is low. Furthermore our data suggest that hyperthyroidism is usually an additional risk factor but rarely the sole risk factor for VT.
David Dw Kim; Sanjeev Chunilal; Simon Young; Rick Cutfield
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-4
Journal Detail:
Title:  Internal medicine journal     Volume:  -     ISSN:  1445-5994     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101092952     Medline TA:  Intern Med J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Internal Medicine Journal © 2012 Royal Australasian College of Physicians.
North Shore Hospital, Takapuna, North Shore City, Auckland, New Zealand. Department of Haematology, Monash Medical Center, Clayton, Victoria, Australia.
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