Document Detail

A study on the toxicity of natural food dyes--toxicity and enzyme inhibition in Paramecium caudatum.
MedLine Citation:
PMID:  39176     Owner:  NLM     Status:  MEDLINE    
The toxicity of 14 commercial natural dyes which are widely used as food additives in Japan was studied on Paramecium caudatum. Laccaic acid and capsanthin were found to be very toxic to Paramecium caudatum. Some of the commercially available carminic acid and crocin were also toxic. The inhibitory effect of natural food dyes on leucine aminopeptidase, acid phosphatase and esterase in vitro was proportional to the toxic effect of the dyes on the survival time of Paramecium caudatum. Analyses of the commercial natural food dyes by high performance liquid chromatography failed to identify the toxic components.
F Sako; N Kobayashi; N Taniguchi; E Takakuwa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of toxicological sciences     Volume:  3     ISSN:  0388-1350     ISO Abbreviation:  J Toxicol Sci     Publication Date:  1978 May 
Date Detail:
Created Date:  1979-11-21     Completed Date:  1979-11-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7805798     Medline TA:  J Toxicol Sci     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  127-36     Citation Subset:  IM    
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MeSH Terms
Acid Phosphatase / antagonists & inhibitors
Esterases / antagonists & inhibitors
Food Coloring Agents / toxicity*
Leucyl Aminopeptidase / antagonists & inhibitors
Paramecium / drug effects*,  enzymology
Time Factors
gamma-Glutamyltransferase / antagonists & inhibitors
Reg. No./Substance:
0/Food Coloring Agents; EC; EC 3.1.-/Esterases; EC Phosphatase; EC Aminopeptidase

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