Document Detail


A study on the toxicity and the biochemical effects of ethylene dibromide in the Japanese quail.
MedLine Citation:
PMID:  7028216     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The acute oral LD50 and chronic LC50 toxicity values for ethylene dibromide (EDB) were estimated for japanese quail. 2. Single sub-acute oral and intraperitoneal doses of EDB (1/2 LD50) and chronic oral doses of EDB (1/3 LC50) were administered to quail in order to characterise the sub-lethal effects of EDB residues. 3. At 24 h after sub-acute dosing, relative liver weight, plasma aspartate aminotransferase (AT) [EC 2.6.1.1] and L-iditol (sorbitol) dehydrogenase (SDH) [EC 1.1.1.14] were elevated and decreases were found in hepatic total lipid, total protein, AT and glutamic dehydrogenase (NAD (P)+) (GDH) and plasma cholinesterase (ChE) [EC 3.1.1.8] and total lipid. 4. Following chronic administration, elevations in relative liver weight, plasma ChE and total lipid, haemoglobin and haematocrit were found and hepatic AT, GDH and total lipid were decreased. 5. The changes in hepatic and plasma enzymes and constituents are discussed in relation to possible biphasic effects resulting from EDB exposure.
Authors:
G E Westlake; P J Bunyan; P I Stanley; C H Walker
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British poultry science     Volume:  22     ISSN:  0007-1668     ISO Abbreviation:  Br. Poult. Sci.     Publication Date:  1981 Jul 
Date Detail:
Created Date:  1982-01-20     Completed Date:  1982-01-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  15740290R     Medline TA:  Br Poult Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  355-64     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetylcholinesterase / blood
Animals
Aspartate Aminotransferases / blood
Coturnix* / blood
Ethylene Dibromide / toxicity*
Female
Glutamate Dehydrogenase / blood
Hydrocarbons, Brominated / toxicity*
L-Iditol 2-Dehydrogenase / blood
Lethal Dose 50
Liver / metabolism
Quail* / blood
Chemical
Reg. No./Substance:
0/Hydrocarbons, Brominated; 106-93-4/Ethylene Dibromide; EC 1.1.1.14/L-Iditol 2-Dehydrogenase; EC 1.4.1.2/Glutamate Dehydrogenase; EC 2.6.1.1/Aspartate Aminotransferases; EC 3.1.1.7/Acetylcholinesterase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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