| A study to determine plasma antioxidant concentrations in patients with Barrett's oesophagus. | |
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MedLine Citation:
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PMID: 15858119 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Dietary questionnaire studies have suggested that patients with oesophageal adenocarcinoma are deficient in antioxidants. It is not known whether the same holds true for patients with the precursor lesion, Barrett's oesophagus. AIMS: To evaluate the hypothesis that patients with Barrett's oesophagus are deficient in antioxidants compared with patients without evidence of Barrett's oesophagus. PATIENTS AND METHODS: Plasma antioxidant profiles (copper, selenium, zinc; vitamins A, C, and E; carotenoids) were determined for patients with Barrett's oesophagus (n = 36), patients with erosive oesophagitis (n = 32), and patient controls (n = 35). RESULTS: Patients with Barrett's oesophagus had significantly lower plasma concentrations of selenium, vitamin C, beta cryptoxanthine, and xanthophyll compared with the other groups. CONCLUSIONS: This study confirms the hypothesis that patients with Barrett's oesophagus are deficient in certain antioxidants. |
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Authors:
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D M Clements; D A Oleesky; S C Smith; H Wheatley; D A Hullin; T J Havard; D J Bowrey |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical pathology Volume: 58 ISSN: 0021-9746 ISO Abbreviation: J. Clin. Pathol. Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-04-28 Completed Date: 2005-06-09 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0376601 Medline TA: J Clin Pathol Country: England |
Other Details:
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Languages: eng Pagination: 490-2 Citation Subset: AIM; IM |
Affiliation:
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Surgery Department, Royal Glamorgan Hospital, Llantrisant CF72 8XR, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Anticarcinogenic Agents / blood Antioxidants / analysis* Ascorbic Acid / blood Barrett Esophagus / blood* Carotenoids / blood Copper / blood Esophagitis / blood Female Humans Male Middle Aged Selenium / blood Vitamin A / blood Vitamin E / blood Xanthophylls / blood Zinc / blood beta Carotene / analogs & derivatives*, blood |
| Chemical | |
Reg. No./Substance:
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0/Anticarcinogenic Agents; 0/Antioxidants; 0/Xanthophylls; 11103-57-4/Vitamin A; 1406-18-4/Vitamin E; 36-88-4/Carotenoids; 472-70-8/cryptoxanthin; 50-81-7/Ascorbic Acid; 502-65-8/lycopene; 7235-40-7/beta Carotene; 7440-50-8/Copper; 7440-66-6/Zinc; 7782-49-2/Selenium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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