Document Detail


A study to determine plasma antioxidant concentrations in patients with Barrett's oesophagus.
MedLine Citation:
PMID:  15858119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Dietary questionnaire studies have suggested that patients with oesophageal adenocarcinoma are deficient in antioxidants. It is not known whether the same holds true for patients with the precursor lesion, Barrett's oesophagus.
AIMS: To evaluate the hypothesis that patients with Barrett's oesophagus are deficient in antioxidants compared with patients without evidence of Barrett's oesophagus.
PATIENTS AND METHODS: Plasma antioxidant profiles (copper, selenium, zinc; vitamins A, C, and E; carotenoids) were determined for patients with Barrett's oesophagus (n = 36), patients with erosive oesophagitis (n = 32), and patient controls (n = 35).
RESULTS: Patients with Barrett's oesophagus had significantly lower plasma concentrations of selenium, vitamin C, beta cryptoxanthine, and xanthophyll compared with the other groups.
CONCLUSIONS: This study confirms the hypothesis that patients with Barrett's oesophagus are deficient in certain antioxidants.
Authors:
D M Clements; D A Oleesky; S C Smith; H Wheatley; D A Hullin; T J Havard; D J Bowrey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  58     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-28     Completed Date:  2005-06-09     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  490-2     Citation Subset:  AIM; IM    
Affiliation:
Surgery Department, Royal Glamorgan Hospital, Llantrisant CF72 8XR, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Anticarcinogenic Agents / blood
Antioxidants / analysis*
Ascorbic Acid / blood
Barrett Esophagus / blood*
Carotenoids / blood
Copper / blood
Esophagitis / blood
Female
Humans
Male
Middle Aged
Selenium / blood
Vitamin A / blood
Vitamin E / blood
Xanthophylls / blood
Zinc / blood
beta Carotene / analogs & derivatives*,  blood
Chemical
Reg. No./Substance:
0/Anticarcinogenic Agents; 0/Antioxidants; 0/Xanthophylls; 11103-57-4/Vitamin A; 1406-18-4/Vitamin E; 36-88-4/Carotenoids; 50-81-7/Ascorbic Acid; 6ZIB13GI33/cryptoxanthin; 7235-40-7/beta Carotene; 7440-50-8/Copper; 7440-66-6/Zinc; 7782-49-2/Selenium; SB0N2N0WV6/lycopene
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