| A study to determine the efficacy of treatments for hydrofluoric acid burns. | |
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MedLine Citation:
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PMID: 7673304 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hydrofluoric acid burns are characterized by progressive tissue destruction and severe pain. Fluoride ion chelators, such as salts of calcium and magnesium, have been used to treat these burns. This study was designed to compare the efficacy of several treatment methods that involve the use of these salts. Standard hydrofluoric acid burns were produced on the shaved hindquarters of rats. After being rinsed with water, the chemical burns were treated by one of seven experimental methods. The progress of the chemical burn damage was observed for 1 week by measuring the surface areas of the burns. Calcium gluconate burn jelly, 20% calcium gluconate in water, and 50% aqueous dimethyl sulfoxide did not significantly slow the spread of the burn area. However, subcutaneous injections of calcium gluconate or magnesium sulfate and topical applications of calcium gluconate in a solution of dimethyl sulfoxide significantly slowed the progress of the burns during the first 24 hours and enhanced tissue recovery for the remainder of the observation period. These results indicate that subcutaneous injections of magnesium or calcium salts appear to be more effective than conventional topical applications in the treatment of hydrofluoric acid burns. More significantly, topically applied calcium gluconate combined with a penetration enhancer, such as dimethyl sulfoxide, is as effective as injection treatments in reducing damage caused by hydrofluoric acid. |
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Authors:
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S T Seyb; L Noordhoek; S Botens; M M Mani |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Journal of burn care & rehabilitation Volume: 16 ISSN: 0273-8481 ISO Abbreviation: J Burn Care Rehabil Publication Date: 1995 May-Jun |
Date Detail:
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Created Date: 1995-10-18 Completed Date: 1995-10-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8110188 Medline TA: J Burn Care Rehabil Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 253-7 Citation Subset: IM |
Affiliation:
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University of Kansas Medical Center, Kansas City 66103, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Animals Anti-Inflammatory Agents / administration & dosage, therapeutic use* Burns, Chemical / drug therapy*, pathology Calcium Gluconate / administration & dosage, therapeutic use* Chelating Agents / administration & dosage, therapeutic use* Combined Modality Therapy Dimethyl Sulfoxide / administration & dosage, therapeutic use* Disease Models, Animal Drug Therapy, Combination Female Hydrofluoric Acid / adverse effects* Injections, Subcutaneous Magnesium Sulfate / administration & dosage, therapeutic use* Rats Rats, Sprague-Dawley Skin / drug effects, pathology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Chelating Agents; 299-28-5/Calcium Gluconate; 67-68-5/Dimethyl Sulfoxide; 7487-88-9/Magnesium Sulfate; 7664-39-3/Hydrofluoric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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