| A study to determine the active moiety of sulphasalazine in rheumatoid arthritis. | |
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MedLine Citation:
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PMID: 2873245 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thirty patients with active rheumatoid arthritis (RA) participated in an open study of 6 months' treatment with either 5-aminosalicylic acid (5-ASA) or sulphapyridine (SP), the two moieties of sulphasalazine (SASP). Patients were assessed at regular intervals using clinical and biochemical tests designed to detect specific antirheumatic activity. Patients taking SP showed significant improvement in disease activity, but those taking 5-ASA did not improve, despite the fact that high serum concentrations of 5-ASA and acetyl 5-ASA were achieved. These results suggest that SP is the active moiety of SASP. Its possible mode of action is discussed. Nausea was a frequent problem in patients taking SP. Unless this can be overcome, SP is unlikely to offer any therapeutic advantages over SASP in the treatment of RA. |
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Authors:
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V C Neumann; A J Taggart; P Le Gallez; C Astbury; J Hill; H A Bird |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of rheumatology Volume: 13 ISSN: 0315-162X ISO Abbreviation: J. Rheumatol. Publication Date: 1986 Apr |
Date Detail:
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Created Date: 1986-08-06 Completed Date: 1986-08-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: CANADA |
Other Details:
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Languages: eng Pagination: 285-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aminosalicylic Acids / therapeutic use Arthritis, Rheumatoid / blood, drug therapy*, physiopathology Female Humans Male Mesalamine Middle Aged Nausea / chemically induced Sulfapyridine / adverse effects, therapeutic use Sulfasalazine / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Aminosalicylic Acids; 144-83-2/Sulfapyridine; 599-79-1/Sulfasalazine; 89-57-6/Mesalamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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