Document Detail


A study to assess the plaque inhibitory action of a newly formulated triclosan toothpaste.
MedLine Citation:
PMID:  11142672     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/AIMS: Triclosan containing toothpastes have been noted for their potential to inhibit plaque and gingival inflammation. The aim of this study was to determine whether a toothpaste containing triclosan and an enhanced fluoride system would inhibit de novo plaque formation beyond that of a non-triclosan, conventional fluoride toothpaste. METHODS: This study used a 4-day plaque regrowth model in which 24 volunteers used toothpaste rinses as the only form of oral hygiene. Following a prophylaxis and a single brushing with the toothpastes, 2x daily rinsing with toothpaste slurries was used over the following 96 h. RESULTS: After 24 h, there was no difference in plaque area between the triclosan paste and its control paste. After 96 h, a reduction in plaque score of 5% was noted for the test toothpaste compared to the control paste which was statistically significant (p=0.028). For plaque area this reduction was increased to 16%, which was also significant (p=0.006). CONCLUSIONS: These findings would appear to warrant further investigation into the potential value of the paste in inhibiting both plaque and gingivitis.
Authors:
J Moran; M Addy; R G Newcombe; I Marlow
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of clinical periodontology     Volume:  28     ISSN:  0303-6979     ISO Abbreviation:  J. Clin. Periodontol.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-01-04     Completed Date:  2001-03-01     Revised Date:  2006-10-30    
Medline Journal Info:
Nlm Unique ID:  0425123     Medline TA:  J Clin Periodontol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  86-9     Citation Subset:  D; IM    
Affiliation:
Department of Oral & Dental Science, University of Bristol, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anti-Infective Agents, Local / therapeutic use*
Cross-Over Studies
Dental Plaque / prevention & control*
Double-Blind Method
Female
Humans
Male
Statistics, Nonparametric
Toothpaste / therapeutic use*
Triclosan / therapeutic use*
Chemical
Reg. No./Substance:
0/Anti-Infective Agents, Local; 0/Toothpaste; 3380-34-5/Triclosan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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