Document Detail


A study of the time course of conversion of edematous to hemorrhagic pancreatitis.
MedLine Citation:
PMID:  2033324     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the conversion of acute edematous pancreatitis (AEP) to acute hemorrhagic pancreatitis (AHP) in an experimental model in cats. In the model, 16,16 dimethyl PgE2 effects this conversion by increasing microvascular permeability. First, we induced AEP in cats and then gave PgE2 at increasing intervals after the induction of AEP to see how long an interval would still allow conversion. In 6 groups of cats, PgE2 was administered for 2 h, starting at 2, 4, 6, 8, 10, or 12 h after the creation of AEP. Twelve h later, the cats were sacrificed and the pancreases were graded for inflammation and hemorrhage. Significant pancreatic hemorrhage did not occur when the PgE2 was administered at 12 h compared to 2 h. Next, we determined that PgE2 still retained its ability to increase pancreatic vascular permeability when administered 12 h after the creation of AEP. This was done by perfusing a marker molecule through the MPD (fluorescein isothiocyanate labeled dextran: FITC-D, mol wt 20,000) and then finding it in portal venous blood (PVB). The presence of FITC-D in PVB signified increased vascular permeability, since normally none was present. We concluded that conversion of AEP to AHP was possible during the first 12 h after induction of AEP. Lack of conversion at 12 h was not caused by a lack of vascular reactivity at that time.
Authors:
N D Karanjia; S M Singh; V Porter-Fink; A L Widdison; H A Reber
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of pancreatology : official journal of the International Association of Pancreatology     Volume:  8     ISSN:  0169-4197     ISO Abbreviation:  Int. J. Pancreatol.     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-06-24     Completed Date:  1991-06-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8703511     Medline TA:  Int J Pancreatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  133-9     Citation Subset:  IM    
Affiliation:
Department of Surgery, VA Medical Center, Sepulveda, CA.
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MeSH Terms
Descriptor/Qualifier:
16,16-Dimethylprostaglandin E2 / administration & dosage
Acute Disease
Animals
Capillary Permeability / drug effects
Cats
Disease Models, Animal
Edema / etiology,  pathology
Gastrointestinal Hemorrhage / etiology,  pathology
Pancreatic Juice / enzymology
Pancreatitis / etiology*,  pathology
Time Factors
Chemical
Reg. No./Substance:
39746-25-3/16,16-Dimethylprostaglandin E2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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