Document Detail

A study of the susceptibility of three species of primate to vaginal colonization with Gardnerella vaginalis.
MedLine Citation:
PMID:  6611168     Owner:  NLM     Status:  MEDLINE    
In an attempt to develop an animal model of Gardnerella-associated vaginitis, several strains of Gardnerella vaginalis were inoculated into the lower genital tract of female pig-tailed macaques, tamarins and chimpanzees. G. vaginalis was not recovered from either tamarins or chimpanzees, but was recovered from each of 1O pig-tailed macaques inoculated with either of two freshly isolated Gardnerella strains, colonization persisting for 11-39 days. Examination of Gram-stained vaginal smears obtained from infected pig-tailed macaques failed to demonstrate clue cells, a feature which is pathognomonic of Gardnerella-associated vaginitis in humans. Other features characteristic of non-specific vaginitis, namely an increase in vaginal pH, and an increase in the ratio of succinate to lactate (S/L ratio) in vaginal fluid were not found. However, the physiology of the macaque vagina was found to be different from that of the human, the vaginal pH and S/L ratio of uninfected macaques both being higher than that seen in humans. The physiological differences between the macaque and human vagina may be due, in part, to a difference in their anaerobic vaginal flora. While these inter-species differences in vaginal physiology and microbiology limit the relevance of the pig-tailed macaque as a model of Gardnerella-associated vaginitis, the ease with which macaques are colonized with G. vaginalis may prove useful in studying bacterial adhesion and local immunity.
A P Johnson; C A Ison; C M Hetherington; M F Osborn; G Southerton; W T London; C S Easmon; D Taylor-Robinson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of experimental pathology     Volume:  65     ISSN:  0007-1021     ISO Abbreviation:  Br J Exp Pathol     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1984-08-29     Completed Date:  1984-08-29     Revised Date:  2012-05-07    
Medline Journal Info:
Nlm Unique ID:  0372543     Medline TA:  Br J Exp Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  389-96     Citation Subset:  IM    
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MeSH Terms
Bacteria, Aerobic / isolation & purification
Disease Models, Animal
Disease Susceptibility
Fatty Acids / analysis
Gardnerella vaginalis / isolation & purification*
Haemophilus / isolation & purification*
Haemophilus Infections / microbiology
Hydrogen-Ion Concentration
Macaca nemestrina
Pan troglodytes
Vagina / microbiology*
Vaginal Smears
Vaginitis / microbiology
Reg. No./Substance:
0/Fatty Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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