| A study of the susceptibility of three species of primate to vaginal colonization with Gardnerella vaginalis. | |
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MedLine Citation:
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PMID: 6611168 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In an attempt to develop an animal model of Gardnerella-associated vaginitis, several strains of Gardnerella vaginalis were inoculated into the lower genital tract of female pig-tailed macaques, tamarins and chimpanzees. G. vaginalis was not recovered from either tamarins or chimpanzees, but was recovered from each of 1O pig-tailed macaques inoculated with either of two freshly isolated Gardnerella strains, colonization persisting for 11-39 days. Examination of Gram-stained vaginal smears obtained from infected pig-tailed macaques failed to demonstrate clue cells, a feature which is pathognomonic of Gardnerella-associated vaginitis in humans. Other features characteristic of non-specific vaginitis, namely an increase in vaginal pH, and an increase in the ratio of succinate to lactate (S/L ratio) in vaginal fluid were not found. However, the physiology of the macaque vagina was found to be different from that of the human, the vaginal pH and S/L ratio of uninfected macaques both being higher than that seen in humans. The physiological differences between the macaque and human vagina may be due, in part, to a difference in their anaerobic vaginal flora. While these inter-species differences in vaginal physiology and microbiology limit the relevance of the pig-tailed macaque as a model of Gardnerella-associated vaginitis, the ease with which macaques are colonized with G. vaginalis may prove useful in studying bacterial adhesion and local immunity. |
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Authors:
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A P Johnson; C A Ison; C M Hetherington; M F Osborn; G Southerton; W T London; C S Easmon; D Taylor-Robinson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of experimental pathology Volume: 65 ISSN: 0007-1021 ISO Abbreviation: Br J Exp Pathol Publication Date: 1984 Jun |
Date Detail:
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Created Date: 1984-08-29 Completed Date: 1984-08-29 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 0372543 Medline TA: Br J Exp Pathol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 389-96 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bacteria, Aerobic / isolation & purification Disease Models, Animal Disease Susceptibility Fatty Acids / analysis Female Gardnerella vaginalis / isolation & purification* Haemophilus / isolation & purification* Haemophilus Infections / microbiology Hydrogen-Ion Concentration Macaca nemestrina Pan troglodytes Saguinus Vagina / microbiology* Vaginal Smears Vaginitis / microbiology |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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