| A study of the supposed hydroxylation of tyrosine catalysed by peroxidase. | |
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MedLine Citation:
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PMID: 1275895 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The claim that peroxidase (rather than tyrosinase) is the enzyme responsible for the conversion of tyrosine into dopa (3,4-dihydroxyphenylalanine) in melanogenesis was investigated. The spectral changes that occurred during the action of horseradish peroxidase in the presence of H2O2 on dopa, tyrosine and mixtures of dopa with tyrosine or other phenolic compounds were studied. The effect of ascorbic acid or dihydroxyfumaric acid on some of these changes was also investigated. No evidence was found that tyrosine was hydroxylated by peroxidase in the presence of H2O2 and dopa as cofactor, although tyrosine or other phenolic compounds increased the rate of oxidation of dopa to dopachrome (indoline-5,6-quinone-2-carboxylic acid). Peroxidase was, however, effective in oxidizing tyrosine to dopa in the presence of dihydroxyfumaric acid and oxygen. |
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Authors:
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P I Smith; G A Swan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Biochemical journal Volume: 153 ISSN: 0264-6021 ISO Abbreviation: Biochem. J. Publication Date: 1976 Feb |
Date Detail:
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Created Date: 1976-08-02 Completed Date: 1976-08-02 Revised Date: 2010-09-07 |
Medline Journal Info:
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Nlm Unique ID: 2984726R Medline TA: Biochem J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 403-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Ascorbic Acid Dihydroxyphenylalanine Fumarates Horseradish Peroxidase / metabolism* Hydrogen Peroxide Hydroxylation Peroxidases / metabolism* Phenols Tyrosine / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Fumarates; 0/Phenols; 50-81-7/Ascorbic Acid; 55520-40-6/Tyrosine; 63-84-3/Dihydroxyphenylalanine; 7722-84-1/Hydrogen Peroxide; EC 1.11.1.-/Horseradish Peroxidase; EC 1.11.1.-/Peroxidases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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