Document Detail

A study of the structural response of wet hyaline cartilage to various loading situations.
MedLine Citation:
PMID:  6450024     Owner:  NLM     Status:  MEDLINE    
A direct view has been obtained of the manner in which the fibrous components components and chondrocytes in hyaline cartilage respond to the application of uniaxial tensile loading and plane-strain compressive loading. A micro-mechanical testing device has been developed which inserts directly into the stage of a high-resolution optical microscope fitted with Nomarski interference contrast and this has permitted simultaneous morphological and mechanical observations to be conducted on articular cartilage maintained in its wet functional condition. Aligned and crimped fibrous arrays surround the deeper chondrocytes and can be observed to undergo well-defined geometric changes with applied stress. It is thought that these arrays may act as displacement or strain sensors transmitting mechanical information from the bulk matrix to their associated cells thus inducing a specific metabolic response. The process of tissue recovery following sustained high levels of compressive loading can also be observed with this experimental technique.
N D Broom; D B Myers
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Connective tissue research     Volume:  7     ISSN:  0300-8207     ISO Abbreviation:  Connect. Tissue Res.     Publication Date:  1980  
Date Detail:
Created Date:  1981-03-24     Completed Date:  1981-03-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0365263     Medline TA:  Connect Tissue Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  227-37     Citation Subset:  IM; S    
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MeSH Terms
Cartilage / cytology,  physiology*
Stress, Mechanical

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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