Document Detail

A study of the sensitization rate to cocamidopropyl betaine in patients patch tested in a university hospital of Beijing.
MedLine Citation:
PMID:  18154554     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The prevalence of sensitization to cocamidopropyl betaine (CAPB) in China has not been reported. OBJECTIVE: This study is to evaluate the prevalence of CAPB sensitization in patients patch tested in Peking University Third Hospital, Beijing. METHODS: 429 consecutive patients with suspected allergic contact dermatitis were patch tested with CAPB 1.0% aqueous, 3-dimethylaminopropylamine (DMAPA) 1.0% aqueous as well as a modified European standard series of allergens from June 2005 to August 2006. RESULTS: 42 patients (9.8%) had a positive reaction to CAPB. 25 of them (59.5%) were considered relevant. Of those, 7 were head and/or neck dermatitis, 4 hand dermatitis, 1 cheilitis, and the other 13 patients were widespread dermatitis. 10 out of 429 (2.3%) patients reacted to DMAPA. Of those, 8 were relevant and 6 of them also reacted to CAPB. CONCLUSION: The rate of CAPB sensitization in our study is higher than previously reported elsewhere. CAPB is a common cosmetic allergen in Beijing. Both CAPB and DMAPA should be tested in patients with suspected cosmetic dermatitis.
Lin-Feng Li
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Contact dermatitis     Volume:  58     ISSN:  1600-0536     ISO Abbreviation:  Contact Derm.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-24     Completed Date:  2008-02-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7604950     Medline TA:  Contact Dermatitis     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  24-7     Citation Subset:  IM    
Department of Dermatology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing 100083, China.
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MeSH Terms
Aged, 80 and over
Betaine / adverse effects,  analogs & derivatives*
China / epidemiology
Cosmetics / adverse effects*
Dermatitis, Allergic Contact / diagnosis,  epidemiology,  etiology*
Diamines / adverse effects*
Hospitals, University
Middle Aged
Patch Tests
Surface-Active Agents / adverse effects*
Reg. No./Substance:
0/Cosmetics; 0/Diamines; 0/Surface-Active Agents; 0/cocamidopropyl betaine; 107-43-7/Betaine; 109-55-7/3-dimethylaminopropylamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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