| A study of sensitivity to curare in myasthenic disorders using a regionaltechnique. | |
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MedLine Citation:
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PMID: 1117298 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A study of curare sensitivity has been made in ocular myasthenia, myasthenia gravis, and the myasthenic syndrome sometimes associated with carcinoma, using a regional technique. Sensitivity is greater than in normal subjects. The injection of 0-125 mg d-tubocurarine resulted in a neuromuscular transmission block in all but a few of those cases with ocular myasthenia and in all cases of generalized myasthenia. Furthermore, the block persisted for longer than in normal subjects after the release of the tourniquet. This sensitivity to curare was not directly related to myasthenic weakness. The reasons for this are discussed and an explanation for such curare sensitivity is suggested. |
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Authors:
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J C Brown; J E Charlton |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of neurology, neurosurgery, and psychiatry Volume: 38 ISSN: 0022-3050 ISO Abbreviation: J. Neurol. Neurosurg. Psychiatr. Publication Date: 1975 Jan |
Date Detail:
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Created Date: 1975-05-29 Completed Date: 1975-05-29 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985191R Medline TA: J Neurol Neurosurg Psychiatry Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 27-33 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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drug effects* Adult Aged Bronchial Neoplasms / diagnosis Carcinoma / diagnosis Electric Stimulation Electromyography Evoked Potentials / drug effects* Humans Middle Aged Muscles / drug effects* Muscular Diseases / diagnosis* Myasthenia Gravis / diagnosis* Neuromuscular Junction / drug effects Oculomotor Muscles / drug effects Time Factors Tubocurarine / diagnostic use*, pharmacology |
| Chemical | |
Reg. No./Substance:
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57-95-4/Tubocurarine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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