Document Detail

A study on the role of cholinergic and gamma amino butyric acid systems in the anti-nociceptive effect of gossypin.
MedLine Citation:
PMID:  8467574     Owner:  NLM     Status:  MEDLINE    
1. The participation of cholinergic and gamma amino butyric acid (GABA) neurotransmitter systems in the anti-nociceptive effect of gossypin was investigated using pharmacological tools. 2. Physostigmine potentiated its anti-nociceptive response while atropine failed to modify it significantly. 3. THIP (4,5,6,7-tetra hydroisoxazolo (5,4-C) pyridin-3-ol) and gossypin treatment produced an additive response while bicuculline attenuated the anti-nociceptive response of gossypin. Similar observations were recorded for morphine. 4. It is suggested that cholinergic and GABAergic systems play a role in gossypin-induced anti-nociception.
S Viswanathan; P Thirugnanasambantham; S Ramaswamy; J S Bapna
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  20     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-05-07     Completed Date:  1993-05-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  193-6     Citation Subset:  IM    
Medicinal Chemistry Research Centre, Madras Medical College, India.
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MeSH Terms
Analgesics / pharmacology*
Flavonoids / pharmacology*
Isoxazoles / pharmacology
Morphine / pharmacology
Pain Measurement / drug effects
Parasympathetic Nervous System / physiology*
Parasympathomimetics / pharmacology
gamma-Aminobutyric Acid / physiology*
Reg. No./Substance:
0/Analgesics; 0/Flavonoids; 0/Isoxazoles; 0/Parasympathomimetics; 56-12-2/gamma-Aminobutyric Acid; 57-27-2/Morphine; 64603-91-4/4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol; 652-78-8/gossypin

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