Document Detail


A study on the role of cholinergic and gamma amino butyric acid systems in the anti-nociceptive effect of gossypin.
MedLine Citation:
PMID:  8467574     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The participation of cholinergic and gamma amino butyric acid (GABA) neurotransmitter systems in the anti-nociceptive effect of gossypin was investigated using pharmacological tools. 2. Physostigmine potentiated its anti-nociceptive response while atropine failed to modify it significantly. 3. THIP (4,5,6,7-tetra hydroisoxazolo (5,4-C) pyridin-3-ol) and gossypin treatment produced an additive response while bicuculline attenuated the anti-nociceptive response of gossypin. Similar observations were recorded for morphine. 4. It is suggested that cholinergic and GABAergic systems play a role in gossypin-induced anti-nociception.
Authors:
S Viswanathan; P Thirugnanasambantham; S Ramaswamy; J S Bapna
Related Documents :
20074924 - Prophylactic and therapeutic effects of mytilus edulis fatty acids on adjuvant-induced ...
1381384 - Two techniques for electron opaque staining of elastic fibres using tannic acid in fres...
16266794 - 3-farnesyl-2-hydroxybenzoic acid is a new anti-helicobacter pylori compound from piper ...
8593474 - Protective effects of neutral amino acids against amphipathic drug-induced hemolysis.
5054 - Citric acid metabolism in hetero- and homofermentative lactic acid bacteria.
20977884 - An ortholog of fara of aspergillus nidulans is implicated in the transcriptional activa...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  20     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-05-07     Completed Date:  1993-05-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  193-6     Citation Subset:  IM    
Affiliation:
Medicinal Chemistry Research Centre, Madras Medical College, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Analgesics / pharmacology*
Animals
Flavonoids / pharmacology*
Isoxazoles / pharmacology
Male
Mice
Morphine / pharmacology
Pain Measurement / drug effects
Parasympathetic Nervous System / physiology*
Parasympathomimetics / pharmacology
gamma-Aminobutyric Acid / physiology*
Chemical
Reg. No./Substance:
0/Analgesics; 0/Flavonoids; 0/Isoxazoles; 0/Parasympathomimetics; 56-12-2/gamma-Aminobutyric Acid; 57-27-2/Morphine; 64603-91-4/4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol; 652-78-8/gossypin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Biliary hyperpressure in rat extrahepatic cholestasis alters horseradish peroxidase biliary excretio...
Next Document:  Differences in the expression of spondyloarthropathy: a comparison between ankylosing spondylitis an...