Document Detail


[The study on the relationship between human papillomavirus infection and pathogenesis of nasal inverted papilloma and its malignant transformation].
MedLine Citation:
PMID:  20464987     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the relationship between human papillomavirus (HPV) infection and pathogenesis of nasal inverted papilloma (NIP) and its malignant transformation.
METHOD: Fifty-seven cases of NIP were divided into 2 groups: benign group, squamous cell carcinoma (SCC) arising in NIP group (malignancy group). HPV-DNA types of 6, 11, 16, 18 were detected by polymerase chain reaction (PCR) in 57 cases of NIP. Thirty cases of nasal polyps were control.
RESULT: Total positive rate of HPV in NIP was 64.9% (37/57). The positive rate of benign group was 60% (27/45), all with single and low risk HPV11 type infection. The positive rate of malignancy group were was 83.3% (10/12), and the majority were HPV16 and HPV18. Five cases had double infection (4 with HPV16 and HPV 18, 1 with HPV11 and HPV18), four had single HPV16 infection, another one had single HPV11 infection. However, HPV-DNA was not detected in any cases of nasal polyps.
CONCLUSION: Infection of HPV-DNA has an important effect in pathogenesis of NIP. Meanwhile, there maybe a close relationship between high risk HPV16 type and HPV18 type and malignant transformation of NIP.
Authors:
Zhenhua Zhong; Aihui Yan; Feifei Jiang; Hongquan Wei; Xuejun Jiang
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery     Volume:  24     ISSN:  1001-1781     ISO Abbreviation:  Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-05-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101303164     Medline TA:  Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi     Country:  China    
Other Details:
Languages:  chi     Pagination:  209-11     Citation Subset:  IM    
Affiliation:
Department of Otorhinolaryngology-Head and Neck Surgery, the First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  [Research of the nasal sinusitis incidence of children in Kunming of Yunnan Province].
Next Document:  [Eighteen cases of plerosising intra-orbital wall blow-out fracture with the nasal septal cartilage ...