| A study of the quantity of some stable and labile coagulation factors in fresh-frozen plasma produced from whole blood stored for 24 hours in Iran. | |
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MedLine Citation:
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PMID: 19290079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim of this study was to assess whether the quantities of some coagulation factors in fresh-frozen plasma (FFP) produced from whole blood stored at 4 degrees C for 24 h are adequate for their intended purpose. MATERIALS AND METHODS: The amounts of some coagulation factors (fibrinogen, FV, FVII, FVIII, FX and FXI) in FFP separated from whole blood after storage at 4 degrees C for 24 h were compared with the amounts of the corresponding coagulation factors in FFP separated from whole blood within 8 h of donation. RESULTS: In 98% of the FFP units prepared after 24 h of storage, the levels of fibrinogen, FV, FVII, FX and FXI were greater than 0.5 IU/mL. The concentration of FVIII in the 24 h plasma units was 82% of that found in the FFP units prepared within 8 h of blood collection. In FFP, FVIII, FVII and FX were reduced by 38%, 8% and 3%, respectively, but FV, FXI and fibrinogen were not reduced. CONCLUSION: These data suggest that there is good retention of coagulation factor activity in plasma produced from whole blood stored at 4 masculineC for 24 h and that such plasma would be an acceptable product for most patients requiring FFP. |
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Authors:
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Hossin Timori Naghadeh; Mehryar Habibi Roudkenar |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Blood transfusion = Trasfusione del sangue Volume: 7 ISSN: 1723-2007 ISO Abbreviation: - Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-03-17 Completed Date: 2009-05-04 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 101237479 Medline TA: Blood Transfus Country: Italy |
Other Details:
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Languages: eng Pagination: 39-42 Citation Subset: IM |
Affiliation:
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Research Center, Iranian Blood Transfusion Organization, Tehran, Iran. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Coagulation Factors
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chemistry,
metabolism* Blood Preservation Cold Temperature Humans Iran Plasma / chemistry, metabolism* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Blood Coagulation Factors |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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