| A study of the protective function of acute morphine administration on subsequent posttraumatic stress disorder. | |
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MedLine Citation:
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PMID: 19058787 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: To index the extent to which acute administration of morphine is protective against development of posttraumatic stress disorder (PTSD). METHODS: Consecutive patients admitted to hospital after traumatic injury (n=155) were assessed for current psychiatric disorder, pain, and morphine dose in the initial week after injury and were reassessed for PTSD and other psychiatric disorders 3 months later (n=120). RESULTS: Seventeen patients (14%) met criteria for PTSD at 3 months. Patients who met criteria for PTSD received significantly less morphine than those who did not develop PTSD; there was no difference in morphine levels in those who did and did not develop major depressive episode or another anxiety disorder. Hierarchical regression analysis indicated that PTSD severity at 3 months was significantly predicted by acute pain, mild traumatic brain injury, and elevated morphine dose in the initial 48 hours after trauma, after controlling for injury severity, gender, age, and type of injury. CONCLUSIONS: Acute administration of morphine may limit fear conditioning in the aftermath of traumatic injury and may serve as a secondary prevention strategy to reduce PTSD development. |
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Authors:
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Richard A Bryant; Mark Creamer; Meaghan O'Donnell; Derrick Silove; Alexander C McFarlane |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-12-05 |
Journal Detail:
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Title: Biological psychiatry Volume: 65 ISSN: 1873-2402 ISO Abbreviation: Biol. Psychiatry Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-02-09 Completed Date: 2009-05-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0213264 Medline TA: Biol Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 438-40 Citation Subset: IM |
Affiliation:
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School of Psychiatry, University of New South Wales, New South Wales, Sydney, Australia. r.bryant@unsw.edu.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analgesics, Opioid / administration & dosage*, therapeutic use Fear Female Humans Male Morphine / administration & dosage*, therapeutic use Psychiatric Status Rating Scales Severity of Illness Index Stress Disorders, Post-Traumatic / prevention & control* Time Factors Wounds and Injuries / complications, drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 57-27-2/Morphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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