Document Detail

A study of piglets born by spontaneous parturition under uncontrolled conditions: could this be a naturalistic model for the study of intrapartum asphyxia?
MedLine Citation:
PMID:  17687814     Owner:  NLM     Status:  MEDLINE    
In order to evaluate how spontaneously born piglets could be a suitable model for the study of intrapartum hypoxia, 230 newborn piglets were studied. Out them, 8.3% (n = 19) died intrapartum, 21.7% (n = 50) were born with moderate-to-severe intrapartum hypoxia, and 70% (n = 161) were born with mild or no evidence of intrapartum distress. Piglets born without any evidence of intrapartum asphyxia weighed approximately 240 g lower than those born with intrapartum hypoxia and intrapartum-dead piglets (P<0.0001). The viability score was approximately 3 units lower and the latency to contact the udder was two times longer in the piglets surviving intrapartum hypoxia than in controls (P <0.0001). In comparison with the control group, metabolic acidosis was most severe among intrapartum-dead piglets followed by piglets surviving intrapartum asphyxia (P =0.002). According to a multiple linear regression analysis, pCO2 and lactate blood levels, and birth weight were identified as explanatory variables of viability score (r: 0.78; P <0.001). Viability score, K+ and lactate blood levels, and birth weight were identified as explanatory variables of latency to contact the udder (r: 0.80; P <0.001). In conclusion, the spontaneously-born asphyxiated piglet could be considered as a naturalistic model for the study of intrapartum asphyxia. Histopathologic and more rigorous functional and behavioral evaluations are still required to further characterize the model. (
Maria E Trujillo-Ortega; Daniel Mota-Rojas; Adriana Olmos-Hernández; María Alonso-Spilsbury; Miguel González; Héctor Orozco; Ramiro Ramírez-Necoechea; Alejandro A Nava-Ocampo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta bio-medica : Atenei Parmensis     Volume:  78     ISSN:  0392-4203     ISO Abbreviation:  -     Publication Date:  2007  
Date Detail:
Created Date:  2007-08-10     Completed Date:  2007-10-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101295064     Medline TA:  Acta Biomed     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  29-35     Citation Subset:  IM    
Department of Animal Medicine and Production: Swine, Faculty of Veterinary and Animal Production, Universidad Nacional Autónoma de México, Ciudad Universitaria, México.
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MeSH Terms
Animals, Newborn
Asphyxia Neonatorum*
Disease Models, Animal*
Infant, Newborn

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