Document Detail

A study of the photo-degradation kinetics of nifedipine by multivariate curve resolution analysis.
MedLine Citation:
PMID:  12684114     Owner:  NLM     Status:  MEDLINE    
A multivariate curve resolution method based on the combination of Kubista approach and iterative target transformation method of Gemperline has been proposed. This method is a soft model and need no information about the spectrum of the product and mechanism of the reaction. The method was used to study the degradation kinetics of nifedipin, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridine dicarboxilic acid dimethyl ester, upon exposure to the light of a 40 W tungsten lamp. The spectra of the nifedipine, collected at different lighting times, were subjected to the factor analysis and two chemical components were detected in the reaction system. Pure spectra of the components involved and their concentration profiles were obtained. The results revealed that the photodecomposition kinetics of nifedipine is zero-order at the beginning of the reaction. However, when the reaction preceded more than 50%, the kinetics of reaction changed to a first-order manner. The rate constants for the zero-order and first order regions were estimated as regions (4.96+/-0.13) x 10(-9) M(-1) s(-1) and (6.22+/-0.10) x 10(-5) s(-1), respectively.
Mojtaba Shamsipur; Bahram Hemmateenejad; Morteza Akhond; Katayoun Javidnia; Ramin Miri
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical and biomedical analysis     Volume:  31     ISSN:  0731-7085     ISO Abbreviation:  J Pharm Biomed Anal     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-09     Completed Date:  2003-12-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309336     Medline TA:  J Pharm Biomed Anal     Country:  England    
Other Details:
Languages:  eng     Pagination:  1013-9     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Elsevier Science B.V.
Department of Chemistry, Razi University, Kermanshah, Iran.
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MeSH Terms
Calcium Channel Blockers / analysis*,  radiation effects
Drug Stability
Multivariate Analysis
Nifedipine / analysis*,  radiation effects
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Solutions; 21829-25-4/Nifedipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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