| A study of the photo-degradation kinetics of nifedipine by multivariate curve resolution analysis. | |
MedLine Citation:
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PMID: 12684114 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A multivariate curve resolution method based on the combination of Kubista approach and iterative target transformation method of Gemperline has been proposed. This method is a soft model and need no information about the spectrum of the product and mechanism of the reaction. The method was used to study the degradation kinetics of nifedipin, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridine dicarboxilic acid dimethyl ester, upon exposure to the light of a 40 W tungsten lamp. The spectra of the nifedipine, collected at different lighting times, were subjected to the factor analysis and two chemical components were detected in the reaction system. Pure spectra of the components involved and their concentration profiles were obtained. The results revealed that the photodecomposition kinetics of nifedipine is zero-order at the beginning of the reaction. However, when the reaction preceded more than 50%, the kinetics of reaction changed to a first-order manner. The rate constants for the zero-order and first order regions were estimated as regions (4.96+/-0.13) x 10(-9) M(-1) s(-1) and (6.22+/-0.10) x 10(-5) s(-1), respectively. |
Authors:
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Mojtaba Shamsipur; Bahram Hemmateenejad; Morteza Akhond; Katayoun Javidnia; Ramin Miri |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pharmaceutical and biomedical analysis Volume: 31 ISSN: 0731-7085 ISO Abbreviation: J Pharm Biomed Anal Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-04-09 Completed Date: 2003-12-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309336 Medline TA: J Pharm Biomed Anal Country: England |
Other Details:
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Languages: eng Pagination: 1013-9 Citation Subset: IM |
Copyright Information:
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Copyright 2003 Elsevier Science B.V. |
Affiliation:
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Department of Chemistry, Razi University, Kermanshah, Iran. mshamsipur@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Calcium Channel Blockers
/
analysis*,
radiation effects Drug Stability Kinetics Light Multivariate Analysis Nifedipine / analysis*, radiation effects Oxidation-Reduction Photochemistry Solutions |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers; 0/Solutions; 21829-25-4/Nifedipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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