Document Detail


A study on novel artificial lung surfactants incorporated with partially fluorinated amphiphiles.
MedLine Citation:
PMID:  22790027     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Lung surfactants (LS), a complex of ∼90 wt% lipids (mainly dipalmitoylphosphatidylcholine or DPPC) and ∼10 wt% surfactant proteins (SP-A, -B, -C, and -D), adsorb to an air-alveolar fluid interface and then lower its surface tension down to near zero during expiration. Intratracheal instillation of exogenous LS preparations can effectively compensate for surfactant deficiency in premature infants with respiratory distress syndrome (RDS). Surfacten<sup>®</sup> (Mitsubishi Tanabe Pharma Corporation, Osaka, Japan), a modified bovine lung extract and an effective surfactant replacement in treatment for RDS patients, is supplemented with DPPC, palmitic acid, and tripalmitin. For the premature infants suffering from RDS, instillation of Surfacten<sup>®</sup> leads to a dramatic improvement in lung function and compliance. Herein, the author reviews potential use of newly designed preparations containing a mimicking peptide of SP-B and also introduces the current research on the preparations incorporated with partially fluorinated amphiphiles to improve their efficacy.
Authors:
Hiromichi Nakahara
Related Documents :
6769937 - Pergolide mesylate: a potent day-long inhibitor of prolactin in rhesus monkeys and pati...
18471797 - Changing patterns of forest malaria among the mobile adult male population in chumkiri ...
12199507 - Comparative studies of female sex pheromone components and male response of the corn st...
1759937 - Selectivity in paternal and infanticidal responses by male mice: effects of relatedness...
23132397 - The efficacy of noninvasive hemoglobin measurement by pulse co-oximetry in neonates.
6605827 - Excessive numbers and activity of peripheral blood b cells in infants with chlamydia tr...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan     Volume:  132     ISSN:  1347-5231     ISO Abbreviation:  Yakugaku Zasshi     Publication Date:  2012  
Date Detail:
Created Date:  2012-07-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413613     Medline TA:  Yakugaku Zasshi     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  817-22     Citation Subset:  IM    
Affiliation:
Department of Biophysical Chemistry, Faculty of Pharmaceutical Sciences, Nagasaki International University.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  [Overview of structural study on conformations and intermolecular interactions of biomolecules].
Next Document:  A Novel Mechanism for Hepatic Lipid Accumulation: A Physiological Role for Hepatic PPAR?-fsp27 Signa...