| A study on novel artificial lung surfactants incorporated with partially fluorinated amphiphiles. | |
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MedLine Citation:
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PMID: 22790027 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Lung surfactants (LS), a complex of ∼90 wt% lipids (mainly dipalmitoylphosphatidylcholine or DPPC) and ∼10 wt% surfactant proteins (SP-A, -B, -C, and -D), adsorb to an air-alveolar fluid interface and then lower its surface tension down to near zero during expiration. Intratracheal instillation of exogenous LS preparations can effectively compensate for surfactant deficiency in premature infants with respiratory distress syndrome (RDS). Surfacten<sup>®</sup> (Mitsubishi Tanabe Pharma Corporation, Osaka, Japan), a modified bovine lung extract and an effective surfactant replacement in treatment for RDS patients, is supplemented with DPPC, palmitic acid, and tripalmitin. For the premature infants suffering from RDS, instillation of Surfacten<sup>®</sup> leads to a dramatic improvement in lung function and compliance. Herein, the author reviews potential use of newly designed preparations containing a mimicking peptide of SP-B and also introduces the current research on the preparations incorporated with partially fluorinated amphiphiles to improve their efficacy. |
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Authors:
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Hiromichi Nakahara |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Volume: 132 ISSN: 1347-5231 ISO Abbreviation: Yakugaku Zasshi Publication Date: 2012 |
Date Detail:
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Created Date: 2012-07-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0413613 Medline TA: Yakugaku Zasshi Country: Japan |
Other Details:
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Languages: eng Pagination: 817-22 Citation Subset: IM |
Affiliation:
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Department of Biophysical Chemistry, Faculty of Pharmaceutical Sciences, Nagasaki International University. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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