Document Detail

A study on the mutagenic activity of styrene and styrene oxide.
MedLine Citation:
PMID:  788148     Owner:  NLM     Status:  MEDLINE    
Styrene oxide is multagenic, without metabolic activation, to S. typhimurium strains TA 1535 and TA 100, which have been devised to detect mutagens causing base-pair substitutions. Styrene seems to be mutagenic toward the same strains, but only after metabolic activation. The toxicity of both styrene and styrene oxide make the construction of reliable dose-response curves rather difficult. Diethylmaleate and 3,3,3-trichloropropene oxide enhanced the mutagenicity of styrene oxide in the presence of homogenate; this result indicates the participation of epoxide hydratase and glutathione S-oxide transferase in the metabolism of styrene oxide. These two chemicals did not influence the mutagenic activity of styrene. Styrene glycol and 4-tert-butyl-brenzcatechin were not mutagenic to any of the strains studied. Results show that further, more detailed experimental and, possibly, epidemiologic studies are warranted.
H Vainio; R Pääkkönen; K Rönnholm; V Raunio; O Pelkonen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of work, environment & health     Volume:  2     ISSN:  0355-3140     ISO Abbreviation:  Scand J Work Environ Health     Publication Date:  1976 Sep 
Date Detail:
Created Date:  1976-12-03     Completed Date:  1976-12-03     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7511540     Medline TA:  Scand J Work Environ Health     Country:  FINLAND    
Other Details:
Languages:  eng     Pagination:  147-51     Citation Subset:  IM    
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MeSH Terms
Epoxide Hydrolases / antagonists & inhibitors
Glutathione / antagonists & inhibitors
Mutation / drug effects*
Salmonella typhimurium / drug effects*
Styrenes / toxicity*
Reg. No./Substance:
0/Styrenes; 70-18-8/Glutathione; EC 3.3.2.-/Epoxide Hydrolases

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