| A study on the mutagenic activity of styrene and styrene oxide. | |
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MedLine Citation:
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PMID: 788148 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Styrene oxide is multagenic, without metabolic activation, to S. typhimurium strains TA 1535 and TA 100, which have been devised to detect mutagens causing base-pair substitutions. Styrene seems to be mutagenic toward the same strains, but only after metabolic activation. The toxicity of both styrene and styrene oxide make the construction of reliable dose-response curves rather difficult. Diethylmaleate and 3,3,3-trichloropropene oxide enhanced the mutagenicity of styrene oxide in the presence of homogenate; this result indicates the participation of epoxide hydratase and glutathione S-oxide transferase in the metabolism of styrene oxide. These two chemicals did not influence the mutagenic activity of styrene. Styrene glycol and 4-tert-butyl-brenzcatechin were not mutagenic to any of the strains studied. Results show that further, more detailed experimental and, possibly, epidemiologic studies are warranted. |
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Authors:
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H Vainio; R Pääkkönen; K Rönnholm; V Raunio; O Pelkonen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Scandinavian journal of work, environment & health Volume: 2 ISSN: 0355-3140 ISO Abbreviation: Scand J Work Environ Health Publication Date: 1976 Sep |
Date Detail:
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Created Date: 1976-12-03 Completed Date: 1976-12-03 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7511540 Medline TA: Scand J Work Environ Health Country: FINLAND |
Other Details:
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Languages: eng Pagination: 147-51 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Epoxide Hydrolases / antagonists & inhibitors Glutathione / antagonists & inhibitors Male Mutation / drug effects* Rats Salmonella typhimurium / drug effects* Styrenes / toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Styrenes; 70-18-8/Glutathione; EC 3.3.2.-/Epoxide Hydrolases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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