| A study of the microheterogeneity of transferrin in cirrhotic patients. | |
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MedLine Citation:
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PMID: 4053385 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to assess the specificity of transferrin molecular changes, we compared concentrations of subfractions and total transferrin in cirrhotic patients, in patients having non-alcoholic hepatitis, in patients with liver cancer, and in controls. The study was carried out in 79 patients divided into four groups: 20 patients with biopsy-proven cirrhosis of alcoholic origin, 20 patients with non-alcoholic hepatitis, 19 patients with liver cancer and 20 controls. Subfractions of serum transferrin were separated by isoelectric focusing followed by direct immunofixation. Fractions pI 5.7 percentages (expressed as percentages of one fraction over total transferrin) were significantly higher in the cirrhotic group than in the control group (p less than 0.01). Fraction pI 5.9 percentages were significantly higher in the cirrhotic group than in the hepatitis or control groups (p less than 0.05), or liver cancer group (p less than 0.01). A quantitative increase of fraction pI 5.7 was found in the cirrhotic patients. However, in this study, this parameter did not discriminate between patients with parenchymal liver diseases of alcoholic or other origin. Therefore, the value of determining fraction pI 5.7 as a marker of chronic alcohol consumption seems questionable. The elevation of fraction pI 5.9 constantly found in the cirrhotic patients could not be explained and needs further investigations. |
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Authors:
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R E Poupon; L Papoz; H Sarmini; R Elinck |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinica chimica acta; international journal of clinical chemistry Volume: 151 ISSN: 0009-8981 ISO Abbreviation: Clin. Chim. Acta Publication Date: 1985 Oct |
Date Detail:
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Created Date: 1985-12-18 Completed Date: 1985-12-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1302422 Medline TA: Clin Chim Acta Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 245-51 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Densitometry Female Hepatitis / blood Humans Immunochemistry Isoelectric Focusing Liver Cirrhosis / blood* Liver Cirrhosis, Alcoholic / blood Liver Neoplasms / blood Male Middle Aged Transferrin / analysis* |
| Chemical | |
Reg. No./Substance:
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11096-37-0/Transferrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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