Document Detail

A study of the microheterogeneity of transferrin in cirrhotic patients.
MedLine Citation:
PMID:  4053385     Owner:  NLM     Status:  MEDLINE    
In order to assess the specificity of transferrin molecular changes, we compared concentrations of subfractions and total transferrin in cirrhotic patients, in patients having non-alcoholic hepatitis, in patients with liver cancer, and in controls. The study was carried out in 79 patients divided into four groups: 20 patients with biopsy-proven cirrhosis of alcoholic origin, 20 patients with non-alcoholic hepatitis, 19 patients with liver cancer and 20 controls. Subfractions of serum transferrin were separated by isoelectric focusing followed by direct immunofixation. Fractions pI 5.7 percentages (expressed as percentages of one fraction over total transferrin) were significantly higher in the cirrhotic group than in the control group (p less than 0.01). Fraction pI 5.9 percentages were significantly higher in the cirrhotic group than in the hepatitis or control groups (p less than 0.05), or liver cancer group (p less than 0.01). A quantitative increase of fraction pI 5.7 was found in the cirrhotic patients. However, in this study, this parameter did not discriminate between patients with parenchymal liver diseases of alcoholic or other origin. Therefore, the value of determining fraction pI 5.7 as a marker of chronic alcohol consumption seems questionable. The elevation of fraction pI 5.9 constantly found in the cirrhotic patients could not be explained and needs further investigations.
R E Poupon; L Papoz; H Sarmini; R Elinck
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  151     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1985-12-18     Completed Date:  1985-12-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  245-51     Citation Subset:  IM    
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MeSH Terms
Hepatitis / blood
Isoelectric Focusing
Liver Cirrhosis / blood*
Liver Cirrhosis, Alcoholic / blood
Liver Neoplasms / blood
Middle Aged
Transferrin / analysis*
Reg. No./Substance:

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