| A study on metals content in patients with colorectal polyps. | |
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MedLine Citation:
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PMID: 18214808 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Data on metals involvement in colorectal polyps are scarce and fragmentary. The aim of this study was to examine whether the level of metals could be associated with risk of colorectal polyp development. The concentration of 15 chemical elements (Al, Ba, Ca, Cd, Co, Cr, Cu, Fe, Hg Mg, Mn, Pb, Se, Sr, and Zn) in 17 colorectal biopsies of healthy individuals, in 15 polypotic and corresponding nonpolypotic biopsies taken from the same individual, was evaluated. Concentration in polyps of metals such as Al, Ca, Mg, Mn, Pb, Sr, and Zn was unchanged both in unpaired and paired samples; elements such as Ba, Cd, and Hg were significantly lower and Fe was significantly higher both in individual and paired tissues. Cobalt, Cr, and Cu were significantly different only between polyps and the adjacent normal tissue area; Se showed a significant accumulation comparing polyps versus healthy tissues. The difference found in some elements between polyps and a control tissue provides an indication about the role of essential and nonessential elements in the early stage (polyps) in the colon carcinogenic process and encourages further studies to confirm the involvement of such elements in neoplastic processes. |
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Authors:
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Alessandro Alimonti; Beatrice Bocca; Antonietta Lamazza; Giovanni Forte; Siavash Rahimi; Daniela Mattei; Enrico Fiori; Maura Iacomino; Alberto Schillaci; Ercole De Masi; Anna Pino |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of toxicology and environmental health. Part A Volume: 71 ISSN: 1528-7394 ISO Abbreviation: J. Toxicol. Environ. Health Part A Publication Date: 2008 |
Date Detail:
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Created Date: 2008-01-24 Completed Date: 2008-02-06 Revised Date: 2008-02-28 |
Medline Journal Info:
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Nlm Unique ID: 100960995 Medline TA: J Toxicol Environ Health A Country: England |
Other Details:
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Languages: eng Pagination: 342-7 Citation Subset: IM |
Affiliation:
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Department of Environment and Primary Prevention, Italian National Institute of Health, Rome, Italy. alessandro.alimonti@iss.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Case-Control Studies Cell Transformation, Neoplastic Colonic Neoplasms / chemistry* Colonic Polyps / chemistry*, pathology* Colonoscopy Female Humans Male Metals, Heavy / analysis* Middle Aged Trace Elements / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Metals, Heavy; 0/Trace Elements |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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