Document Detail

A study for maternal thyroid hormone deficiency during the first half of pregnancy in China.
MedLine Citation:
PMID:  19087128     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Maternal thyroid hormone deficiency is the most common disorder of thyroid function during pregnancy and can influence the outcome for mother and foetus. The purpose of this study was to investigate the prevalence of thyroid hormone deficiency during the first half of pregnancy in iodine sufficient areas of China. MATERIALS AND METHODS: Four thousand eight hundred pregnant women from 10 hospitals during the first 20 weeks of gestation were enrolled in this study. All sera obtained from pregnant women were measured for thyrotropin, free thyroxine and thyroid peroxidase antibody. Screening for thyroid hormone deficiency was performed on pregnant women using gestational age-specific reference intervals or non-pregnant population reference intervals. RESULTS: With gestational age-specific reference intervals as the criterion, the prevalence of subclinical hypothyroidism at 4, 8, 12,16 and 20 weeks of gestation was 4.59%, 6.15%, 4.68%, 4.53% and 5.96%, respectively, and the prevalence of hypothyroxinaemia was 3.69%, 1.11%, 2.92%, 1.29% and 2.29%, respectively. Different prevalence was obtained when non-pregnant population reference intervals was used as the criterion. If non-pregnant population reference intervals were used, the percentage of potentially misclassified cases of subclinical hypothyroidism were 0.18%, 2.85%, 4.1%, 3.24%, and 3.21%, respectively, and 3.45%, 0.66%, 2.34%, 1.29%, and 1.83%, respectively, in potentially misclassified cases of hypothyroxinaemia. CONCLUSIONS: The percentage of potentially misclassified cases of subclinical hypothyroidism and hypothyroxinaemia in pregnant women decreased by using the gestational age-specific reference intervals as a diagnostic criteria during the first half of pregnancy.
Z Y Shan; Y Y Chen; W P Teng; X H Yu; C Y Li; W W Zhou; B Gao; J R Zhou; B Ding; Y Ma; Y Wu; Q Liu; H Xu; W Liu; J Li; W W Wang; Y B Li; C L Fan; H Wang; R Guo; H M Zhang
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of clinical investigation     Volume:  39     ISSN:  1365-2362     ISO Abbreviation:  Eur. J. Clin. Invest.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-17     Completed Date:  2009-07-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0245331     Medline TA:  Eur J Clin Invest     Country:  England    
Other Details:
Languages:  eng     Pagination:  37-42     Citation Subset:  IM    
Department of Endocrinology and Metabolism, First Affiliated Hospital, China Medical University, Shenyang, Liaoning Province, China.
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MeSH Terms
Hypothyroidism / blood*
Pregnancy Complications / blood*
Reference Values
Thyroid Function Tests / methods
Thyroid Gland / physiopathology*
Thyroxine / deficiency*
Reg. No./Substance:

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