Document Detail

A study of liver biopsies and liver disease among hemophiliacs.
MedLine Citation:
PMID:  3926025     Owner:  NLM     Status:  MEDLINE    
Hepatic histologic materials (biopsy or autopsy) and associated clinical data from 155 hemophiliacs were collected by an ad hoc hemophilia study group and analyzed retrospectively in an effort to determine the spectrum of liver disease in this population and to examine the relationship between the severity of liver disease and treatment history. Clinical information on the frequency of complications from 126 biopsies in 115 hemophilic patients provided a unique opportunity to assess the safety of liver biopsy in such patients. The incidence of cirrhosis (15%) and chronic active hepatitis (7%) was lower than previously reported. The frequency of severe liver disease (chronic active hepatitis or cirrhosis) in patients receiving large pooled concentrates was no greater than in patients treated principally with cryoprecipitate or plasma. The risks of liver biopsy in this setting are relatively high: clinically significant hemorrhage followed 12.5% of the procedures.
L M Aledort; P H Levine; M Hilgartner; P Blatt; J A Spero; J D Goldberg; L Bianchi; V Desmet; P Scheuer; H Popper
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Blood     Volume:  66     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  1985 Aug 
Date Detail:
Created Date:  1985-09-11     Completed Date:  1985-09-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  367-72     Citation Subset:  AIM; IM    
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MeSH Terms
Alanine Transaminase / blood
Aspartate Aminotransferases / blood
Blood Transfusion
Factor IX / therapeutic use
Factor VIII / therapeutic use
Hemophilia A / complications*,  therapy
Hepatitis / complications
Liver / pathology*
Liver Cirrhosis / complications
Liver Diseases / blood,  complications*,  pathology
Retrospective Studies
Reg. No./Substance:
9001-27-8/Factor VIII; 9001-28-9/Factor IX; EC Aminotransferases; EC Transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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