Document Detail


A study on the incidence of ABL gene deletion on derivative chromosome 9 in chronic myelogenous leukemia by interphase fluorescence in situ hybridization and its association with disease progression.
MedLine Citation:
PMID:  12759927     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fluorescence in situ hybridization for the BCR/ABL rearrangement in 138 bone marrow specimens from 59 Philadelphia(+) (Ph(+)) chronic myelogenous leukemia (CML) patients, 35 Ph(+) acute lymphoblastic leukemia (ALL) patients, and 57 Ph(-) ALL patients was used. Sixteen (27.1%) of the 59 CML patients had deletions of the residual ABL gene on the derivative chromosome 9. During the study period, 32 of the 59 CML patients progressed to blast crisis or accelerated phase. Of these, nine patients had residual ABL gene deletions on the derivative chromosomes 9 and 23 patients had no deletions. The mean duration from first diagnosis to blast crisis or accelerated phase for the nine patients with ABL deletions was 32.8 months, and for the 23 patients without ABL deletions, it was 62.4 months (P = 0.017). The overall survival time for the 16 patients with deletions was 32.8 months, and for the 43 patients without deletions, it was 60.1 months (P = 0.164). ABL deletions were not detected among the 35 ALL patients (17 with major BCR/ABL, 18 with minor BCR/ABL), and it appears that this deletion occurs rarely or not at all in Ph(+) ALL patients, which is in contrast to the CML patients (27.1%). However, we detected two ALL cases with ABL deletion but without BCR/ABL rearrangement among 49 Ph(-) ALL and 66 Ph(-) AML patients. In conclusion, patients with ABL deletions progress to blast crisis or accelerated phase in a significantly shorter time than do those without such deletions. It is therefore suggested that the ABL deletion is an indicator of a poor prognosis in CML.
Authors:
Dong Soon Lee; Yun-Song Lee; Yeon-Sook Yun; Young-Ree Kim; Seok San Jeong; Young Kyung Lee; Cha Ja She; Sung Soo Yoon; Hae Rim Shin; Yongsoo Kim; Han Ik Cho
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genes, chromosomes & cancer     Volume:  37     ISSN:  1045-2257     ISO Abbreviation:  Genes Chromosomes Cancer     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-05-21     Completed Date:  2003-07-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9007329     Medline TA:  Genes Chromosomes Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  291-9     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Wiley-Liss, Inc.
Affiliation:
Department of Clinical Pathology, Seoul National University College of Medicine, Korea. soonlee@plaza.snu.ac.kr
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adolescent
Adult
Aged
Blast Crisis / epidemiology,  genetics*
Bone Marrow / chemistry,  metabolism,  pathology
Chromosomes, Human, Pair 9 / genetics*
Disease Progression
Disease-Free Survival
Female
Fusion Proteins, bcr-abl / genetics
Gene Deletion*
Genes, abl / genetics*
Humans
In Situ Hybridization, Fluorescence / methods*
Incidence
Interphase / genetics*
Korea / epidemiology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / epidemiology,  genetics*,  pathology*
Leukemia, Myeloid / genetics
Male
Middle Aged
Philadelphia Chromosome
Chemical
Reg. No./Substance:
0/Fusion Proteins, bcr-abl
Comments/Corrections
Comment In:
Genes Chromosomes Cancer. 2005 Apr;42(4):433-4   [PMID:  15645497 ]
Genes Chromosomes Cancer. 2005 Jun;43(2):223-4; author reply 225   [PMID:  15751036 ]

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