Document Detail


A study of hemostasis in ischemic cerebrovascular disease. I. Abnormalities in factor VIII and antithrombin.
MedLine Citation:
PMID:  6810496     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A sample of in all 119 young adults below the age of 55, with ischemic cerebrovascular disease (TIA and minor stroke), was investigated later than three months after acute disease. Factor VIII biological activity and antithrombin antigen were significantly (p less than 0.001) increased as compared to 80 healthy controls. In combination, these two variables correctly classified 85 percent of patients and controls at a stepwise discriminant analysis. Factor VIII related antigen was increased (p less than 0.02) in patients with atherosclerotic signs at cerebral angiography and in postmenopausal female patients (p less than 0.001). It is suggested that high levels of factor VIII might predispose for thrombosis/atherosclerosis. Antithrombin biological activity was normal in spite of high antithrombin antigen levels, possibly indicating a relative insufficiency in the antithrombin defense line. It is concluded that young stroke patients provide good opportunities to look for early operating factors and predictors in human atherosclerosis and arterial thromboembolism.
Authors:
K L Mettinger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thrombosis research     Volume:  26     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  1982 May 
Date Detail:
Created Date:  1982-10-29     Completed Date:  1982-10-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  183-92     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antithrombin III / metabolism*
Arteriosclerosis / blood
Cerebrovascular Disorders / blood
Factor VIII / metabolism*
Female
Hemostasis
Humans
Male
Menopause
Middle Aged
Risk
Thromboembolism / blood
Chemical
Reg. No./Substance:
9000-94-6/Antithrombin III; 9001-27-8/Factor VIII

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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