Document Detail

A study on the estimation of sulfur-containing amino acid metabolism by the determination of urinary sulfate and taurine.
MedLine Citation:
PMID:  12436211     Owner:  NLM     Status:  MEDLINE    
Sulfate and taurine are major end products of sulfur-containing amino acid metabolism in mammals including humans, and they are excreted in urine. Average excretions micromol/mg of creatinine) in the morning urine of 58 female college students were: total (free plus ester) sulfate (a). 12.53 +/- 3.85; free sulfate, 11.57 +/- 3.69; taurine, 0.78 +/- 0.53. Ratio of total sulfate and taurine was 10 : 0.6. Regression lines obtained by plotting total sulfate, free sulfate, or total sulfate plus taurine against urea have shown that the former excretions are significantly correlated with urea excretion. Excretion of total sulfate at zero point of urea excretion (b). was 5.30, which corresponded to 42.3% of average excretion (12.53) and was assumed to be derived from dietary sulfate. The difference 7.23 (a - b) seemed to be derived from sulfur-containing amino acids. It was pointed out that the difference of average sulfate excretion and sulfate excretion at zero urea excretion, namely a - b, was appropriate for the metabolic index of sulfur-containing amino acids of the group examined. As free sulfate constituted 92.3% of total sulfate, excretion of ester sulfate was at a constant level, and that of taurine was not significantly correlated with urea excretion, the value of free sulfate corresponding to the value a - b of total sulfate mentioned above seemed to be a reliable and convenient index in the assessment of sulfur-containing amino acid metabolism.
H Nakamura; R Kajikawa; T Ubuka
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Amino acids     Volume:  23     ISSN:  0939-4451     ISO Abbreviation:  Amino Acids     Publication Date:  2002  
Date Detail:
Created Date:  2002-11-18     Completed Date:  2003-06-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9200312     Medline TA:  Amino Acids     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  427-31     Citation Subset:  IM    
Department of Clinical Nutrition, Kawasaki University of Medical Welfare, Kurashiki, Okayama, Japan.
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MeSH Terms
Amino Acids / chemistry*,  metabolism*
Creatinine / urine
Regression Analysis
Sulfates / urine*
Taurine / urine*
Urea / urine
Reg. No./Substance:
0/Amino Acids; 0/Sulfates; 107-35-7/Taurine; 57-13-6/Urea; 60-27-5/Creatinine

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