Document Detail


A study of endothelium-dependent proliferation of pulmonary smooth muscle cells in vitro.
MedLine Citation:
PMID:  8326524     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The direct effect of hypoxia and the effect of hypoxic endothelial cells conditioned medium on cultured pulmonary arterial smooth muscle cells in vitro were studied with phase contrast in microscopy, 3H-thymidine labelled technique and flow cytometric measurements. The results showed that direct hypoxia inhibited proliferation of pulmonary arterial smooth muscle cells, retained pulmonary arterial smooth muscle cells in the Go/G1 phase and decreased 3H-thymidine incorporation into pulmonary arterial smooth muscle cells and that hypoxic endothelial cells conditioned medium stimulated proliferation of pulmonary arterial smooth muscle cells, promoted pulmonary arterial smooth muscle cells from G0/G1 phase to S phase and increased 3H-thymidine incorporation into pulmonary arterial smooth muscle cells. It was reasonable to believe that hypoxia might enable pulmonary arterial endothelial cells to secrete some growth factors which could stimulate proliferation of pulmonary arterial smooth muscle cells, thereby playing an important role in structural remodeling of the pulmonary arteries and in the development of hypoxic pulmonary hypertension.
Authors:
F Xiao; D Y Che; W R Zhang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of Tongji Medical University = Tong ji yi ke da xue xue bao     Volume:  13     ISSN:  0257-716X     ISO Abbreviation:  J. Tongji Med. Univ.     Publication Date:  1993  
Date Detail:
Created Date:  1993-08-06     Completed Date:  1993-08-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8605495     Medline TA:  J Tongji Med Univ     Country:  CHINA    
Other Details:
Languages:  eng     Pagination:  10-3     Citation Subset:  IM    
Affiliation:
Department of Pathology, Tongji Medical University, Wuhan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Cycle
Cell Division
Cell Hypoxia*
Cells, Cultured
Endothelial Growth Factors / pharmacology
Endothelium, Vascular / cytology,  physiology*
Muscle, Smooth, Vascular / cytology*
Pulmonary Artery / cytology
Swine
Chemical
Reg. No./Substance:
0/Endothelial Growth Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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