Document Detail


A study of the electrochemistry and osmotic relationships of the cochlear fluids in the neonatal rat at the time of the development of the endocochlear potential.
MedLine Citation:
PMID:  5557069     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Changes in the endocochlear potential between the 8th and 18th days after birth were investigated in the rat. Initially the potential was low but its magnitude increased rapidly between the 11th and 16th day. During the 13th and 14th days the rate of increase was approximately 1 mV/hr.2. The rapid potential increase arose virtually simultaneously in all three turns of the cochlea.3. Histological examination revealed the cochlea, including the hair cells of Corti's organ and the stria vascularis, to be fully mature before the period of rapid change in the endocochlear potential, apart from the cells of Claudius, whose final development coincided with the latter part of this phase.4. The endolymphatic sodium concentration (average 1.0 m-equiv/l.) had attained the very low adult level in the earliest period studied. The potassium and chloride concentrations were slightly below the normal adult levels, the result of some degree of general hypo-osmolality present at this time.5. The endolymphatic ionic concentrations remained unchanged during the phase of rapid increase in the endocochlear potential.6. The findings thus indicate that the distinctive endolymphatic ionic composition and the endocochlear potential arise largely independently and in succession during cochlear maturation.7. No differences in osmotic pressure were demonstrated between endolymph, perilymph and serum. The problems concerning the homoeostasis of the inner ear fluids do not consequently seem to be complicated by unusual hydrodynamic aspects.8. Alterations in body fluid osmolality, produced by intraperitoneal injection of water or hypertonic glycerol, were accompanied by simultaneous changes in the osmotic pressures of the inner ear fluids. Some portion of the membranes bounding the endolymphatic space is therefore considered to be freely permeable to water.9. The investigations provide no further information about the nature of the endocochlear potential, although an increase in the electrical resistance of the cochlear duct membranes is thought responsible for its appearance. The time relationships of this period support the concept that the potential is an essential feature of the mechano-electric transduction process.
Authors:
S K Bosher; R L Warren
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of physiology     Volume:  212     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  1971 Feb 
Date Detail:
Created Date:  1971-09-03     Completed Date:  1971-09-03     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  739-61     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn / physiology*
Cell Membrane Permeability
Chlorides / analysis
Cochlea / growth & development*,  physiology*
Gestational Age
Glycerol / administration & dosage
Homeostasis
Hypertonic Solutions / administration & dosage
Injections, Intraperitoneal
Labyrinthine Fluids / analysis,  physiology*
Membrane Potentials
Organ of Corti
Osmolar Concentration
Osmosis*
Osmotic Pressure
Potassium / analysis
Rats
Sodium / analysis
Time Factors
Water / administration & dosage,  metabolism
Chemical
Reg. No./Substance:
0/Chlorides; 0/Hypertonic Solutions; 56-81-5/Glycerol; 7440-09-7/Potassium; 7440-23-5/Sodium; 7732-18-5/Water
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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