| A study of the efficacy of cleansers for acne vulgaris. | |
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MedLine Citation:
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PMID: 20394494 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Acne treatments are sometimes expensive, and mild acne patients need some simpler form of treatment and, thus, the need for easier and cheaper ways of managing acne is increasing. METHODS: An 8-week, double-blind, randomized clinical trial was conducted to determine whether cleansers are effective at producing clinical improvements in patients with acne vulgaris. A total of 13 acne patients applied cleanser A to one half of the face and cleanser B (cleanser A plus triclosan, salicylic acid, and azelaic acid) to the other half, twice daily. RESULTS: The numbers of inflammatory and non-inflammatory lesions decreased on both sides. A rebound tendency was noted for cleanser A with respect to inflammatory lesions at 4 weeks post-discontinuation, whereas inflammatory lesions continued to decrease on sides treated with cleanser B during this period. However, non-inflammatory lesion counts were not significantly different in the two groups. Though patients were generally satisfied with both treatments, they were more satisfied with cleanser B. Moreover, histopathologic examinations showed a profound decrease in inflammatory reactions in the cleanser B group. CONCLUSION: These results show that acne cleansers reduced both inflammatory and non-inflammatory acne lesion counts, and might be helpful for acne treatment. |
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Authors:
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Yu Sung Choi; Ho Seok Suh; Mi Young Yoon; Seong Uk Min; Jin Sook Kim; Jae Yoon Jung; Dong Hun Lee; Dae Hun Suh |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of dermatological treatment Volume: 21 ISSN: 1471-1753 ISO Abbreviation: J Dermatolog Treat Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-16 Completed Date: 2010-07-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8918133 Medline TA: J Dermatolog Treat Country: England |
Other Details:
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Languages: eng Pagination: 201-5 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Ulsan University Hospital, Ulsan, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acne Vulgaris
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diagnosis*,
drug therapy* Administration, Cutaneous Adult Detergents / therapeutic use* Dicarboxylic Acids Dose-Response Relationship, Drug Double-Blind Method Drug Administration Schedule Female Follow-Up Studies Humans Male Papain / therapeutic use Patient Satisfaction Probability Salicylic Acid / therapeutic use Severity of Illness Index Skin Absorption / drug effects Skin Care / methods* Statistics, Nonparametric Treatment Outcome Triclosan / therapeutic use Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Detergents; 0/Dicarboxylic Acids; 123-99-9/azelaic acid; 3380-34-5/Triclosan; 69-72-7/Salicylic Acid; EC 3.4.22.2/Papain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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