Document Detail


A study of the efficacy of cleansers for acne vulgaris.
MedLine Citation:
PMID:  20394494     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Acne treatments are sometimes expensive, and mild acne patients need some simpler form of treatment and, thus, the need for easier and cheaper ways of managing acne is increasing. METHODS: An 8-week, double-blind, randomized clinical trial was conducted to determine whether cleansers are effective at producing clinical improvements in patients with acne vulgaris. A total of 13 acne patients applied cleanser A to one half of the face and cleanser B (cleanser A plus triclosan, salicylic acid, and azelaic acid) to the other half, twice daily. RESULTS: The numbers of inflammatory and non-inflammatory lesions decreased on both sides. A rebound tendency was noted for cleanser A with respect to inflammatory lesions at 4 weeks post-discontinuation, whereas inflammatory lesions continued to decrease on sides treated with cleanser B during this period. However, non-inflammatory lesion counts were not significantly different in the two groups. Though patients were generally satisfied with both treatments, they were more satisfied with cleanser B. Moreover, histopathologic examinations showed a profound decrease in inflammatory reactions in the cleanser B group. CONCLUSION: These results show that acne cleansers reduced both inflammatory and non-inflammatory acne lesion counts, and might be helpful for acne treatment.
Authors:
Yu Sung Choi; Ho Seok Suh; Mi Young Yoon; Seong Uk Min; Jin Sook Kim; Jae Yoon Jung; Dong Hun Lee; Dae Hun Suh
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of dermatological treatment     Volume:  21     ISSN:  1471-1753     ISO Abbreviation:  J Dermatolog Treat     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-16     Completed Date:  2010-07-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8918133     Medline TA:  J Dermatolog Treat     Country:  England    
Other Details:
Languages:  eng     Pagination:  201-5     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Ulsan University Hospital, Ulsan, Korea.
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MeSH Terms
Descriptor/Qualifier:
Acne Vulgaris / diagnosis*,  drug therapy*
Administration, Cutaneous
Adult
Detergents / therapeutic use*
Dicarboxylic Acids
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Female
Follow-Up Studies
Humans
Male
Papain / therapeutic use
Patient Satisfaction
Probability
Salicylic Acid / therapeutic use
Severity of Illness Index
Skin Absorption / drug effects
Skin Care / methods*
Statistics, Nonparametric
Treatment Outcome
Triclosan / therapeutic use
Young Adult
Chemical
Reg. No./Substance:
0/Detergents; 0/Dicarboxylic Acids; 123-99-9/azelaic acid; 3380-34-5/Triclosan; 69-72-7/Salicylic Acid; EC 3.4.22.2/Papain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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