Document Detail

A study on the effects of inhibition of prostaglandin biosynthesis with flunixin meglumine and later administration of prostaglandin F2 alpha on the intraluminal pressure variations in the isthmus of the oviduct in unrestrained gilts.
MedLine Citation:
PMID:  8266889     Owner:  NLM     Status:  MEDLINE    
Three gilts were each equipped with 2 ultra-miniature pressure sensors, placed at 2 different points along the same isthmus of the oviduct. Following base recordings of isthmic intraluminal pressure, the gilts were treated with 2.2 mg flunixin meglumine (FM) per kg body weight. After FM treatment, the peripheral plasma levels of 15-ketodihydro-PGF2 alpha, the major metabolite of prostaglandin F2 alpha (PGF2 alpha), decreased within 30 min. The frequency of the phasic pressure fluctuations in the isthmus of the oviduct decreased after FM treatment. Exogenous administration of PGF2 alpha increased the peripheral plasma levels of 15-ketodihydro-PGF2 alpha. When administered at a dose of 0.1 mg, PGF2 alpha produced an increase in the frequency of the phasic pressure fluctuations in the oviductal isthmus. When the PGF2 alpha dose was increased to 0.5 mg, a marked increase in the base and total pressures was seen in addition to the increase in the frequency of the phasic pressure fluctuations.
A Pettersson; S Einarsson; H Kindahl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta veterinaria Scandinavica     Volume:  34     ISSN:  0044-605X     ISO Abbreviation:  Acta Vet. Scand.     Publication Date:  1993  
Date Detail:
Created Date:  1994-01-27     Completed Date:  1994-01-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370400     Medline TA:  Acta Vet Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  125-31     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Clonixin / analogs & derivatives*,  pharmacology
Dinoprost / analogs & derivatives*,  antagonists & inhibitors,  biosynthesis,  pharmacology*
Estrus / physiology
Fallopian Tubes / physiology*
Swine / blood,  physiology*
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 17737-65-4/Clonixin; 27376-76-7/15-keto-13,14-dihydroprostaglandin F2alpha; 42461-84-7/flunixin meglumine; 551-11-1/Dinoprost

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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