| A study of the effects of desipramine treatment alone and in combination with L-triiodothyronine on 6-sulphatoxymelatonin excretion in depressed patients. | |
| | |
MedLine Citation:
|
PMID: 2611544 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Urinary 6-sulphatoxymelatonin (alpha MT6s) excretion was measured after one day and one, two and three weeks of desipramine treatment in eight depressed patients. There was significant increase in the urinary excretion of alpha MT6s after one week of treatment, and at no time was there any decrease in alpha MT6s excretion. These findings are opposed to the hypothesis that desipramine reduces noradrenergic neurotransmission in the human pineal. In a further five patients whose depression was resistant to desipramine alone, urinary alpha MT6s excretion was measured during treatment with adjunctive L-triiodothyronine (T3). There was no change in alpha MT6s excretion, and thus the previously reported potentiation of the efficacy of tricyclic antidepressants in combination with T3 does not appear to be mediated through an alteration in noradrenergic neurotransmission. |
| | |
Authors:
|
J Bearn; C Franey; J Arendt; S A Checkley |
Related Documents
:
|
3932134 - Excess dietary aluminum increases drosophila's rate of aging. 16520264 - High-sodium food choices by southern, urban african americans with heart failure. 3802724 - The potential use of lithium as a marker for the assessment of the sources of dietary s... 14682644 - Patterns of fluoride intake from 36 to 72 months of age. 16002194 - An in situ postexposure feeding assay with carcinus maenas for estuarine sediment-overl... 15869184 - Bioindicator organisms: heavy metal pollution evaluation in the ionian sea (mediterrane... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The British journal of psychiatry : the journal of mental science Volume: 155 ISSN: 0007-1250 ISO Abbreviation: Br J Psychiatry Publication Date: 1989 Sep |
Date Detail:
|
Created Date: 1990-02-26 Completed Date: 1990-02-26 Revised Date: 2009-09-29 |
Medline Journal Info:
|
Nlm Unique ID: 0342367 Medline TA: Br J Psychiatry Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 341-7 Citation Subset: IM |
Affiliation:
|
Institute of Psychiatry, University of Surrey. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Depressive Disorder / drug therapy*, urine Desipramine / blood, therapeutic use* Drug Therapy, Combination Female Humans Male Melatonin / analogs & derivatives, urine Middle Aged Time Factors Triiodothyronine / therapeutic use* |
| Grant Support | |
ID/Acronym/Agency:
|
//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
|
2208-41-5/6-hydroxymelatonin; 50-47-5/Desipramine; 6893-02-3/Triiodothyronine; 73-31-4/Melatonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Socio-cultural parameters in Yoruba Nigerian patients with affective disorders.
Next Document: The Scottish survey of new chronic in-patients: five-year follow-up.