Document Detail

A study of the effects of desipramine treatment alone and in combination with L-triiodothyronine on 6-sulphatoxymelatonin excretion in depressed patients.
MedLine Citation:
PMID:  2611544     Owner:  NLM     Status:  MEDLINE    
Urinary 6-sulphatoxymelatonin (alpha MT6s) excretion was measured after one day and one, two and three weeks of desipramine treatment in eight depressed patients. There was significant increase in the urinary excretion of alpha MT6s after one week of treatment, and at no time was there any decrease in alpha MT6s excretion. These findings are opposed to the hypothesis that desipramine reduces noradrenergic neurotransmission in the human pineal. In a further five patients whose depression was resistant to desipramine alone, urinary alpha MT6s excretion was measured during treatment with adjunctive L-triiodothyronine (T3). There was no change in alpha MT6s excretion, and thus the previously reported potentiation of the efficacy of tricyclic antidepressants in combination with T3 does not appear to be mediated through an alteration in noradrenergic neurotransmission.
J Bearn; C Franey; J Arendt; S A Checkley
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of psychiatry : the journal of mental science     Volume:  155     ISSN:  0007-1250     ISO Abbreviation:  Br J Psychiatry     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1990-02-26     Completed Date:  1990-02-26     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  0342367     Medline TA:  Br J Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  341-7     Citation Subset:  IM    
Institute of Psychiatry, University of Surrey.
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MeSH Terms
Depressive Disorder / drug therapy*,  urine
Desipramine / blood,  therapeutic use*
Drug Therapy, Combination
Melatonin / analogs & derivatives,  urine
Middle Aged
Time Factors
Triiodothyronine / therapeutic use*
Grant Support
//Wellcome Trust
Reg. No./Substance:
2208-41-5/6-hydroxymelatonin; 50-47-5/Desipramine; 6893-02-3/Triiodothyronine; 73-31-4/Melatonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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