Document Detail

A study of early pregnancy factor activity in the sera of patients with unexplained spontaneous abortion.
MedLine Citation:
PMID:  8329108     Owner:  NLM     Status:  MEDLINE    
PROBLEM: Seventy-seven sera samples obtained from 51 patients (6-20 wk gestation) with unexplained spontaneous abortions including 20 threatened abortions (TA), 13 inevitable abortions (IA), and 18 intrauterine fetal growth retardation (IFGR), as well as 9 sera from 9 patients (6-20 wk gestation) with hydatidiform mole (HM), were detected for early pregnancy factor (EPF) by rosette inhibition assay. Rosette inhibition titer (RIT) was used to express EPF activity. RESULTS: The RIT value of EPF was 5.95 +/- 0.69 (mean +/- SD) in the TA group; 4.06 +/- 0.93 in the IA group; 3.50 +/- 0.71 in the IFGR group, and 4.00 +/- 0.71 in the HM group. Except for the TA group, in which the mean RIT was in normal pregnancy range, the RIT in the other three groups was significantly lower (P < 0.01) then that of the normal pregnancy group (5.81 +/- 0.68). CONCLUSIONS: These results suggest that measurement of EPF is a sensitive method for judging survival of the embryo. It may be used to predict the prognosis of the patient with unexplained spontaneous abortion.
H Shu-Xin; Z Zhen-Qun
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  29     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-08-16     Completed Date:  1993-08-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  77-81     Citation Subset:  IM    
Research Laboratory of Reproductive Immunology, Shanxi Medical College, Taiyuan, People's Republic of China.
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MeSH Terms
Abortion, Spontaneous / blood*,  immunology
Abortion, Therapeutic
Abortion, Threatened / blood
Chaperonin 10
Fetal Death / blood
Fetal Growth Retardation / blood,  immunology
Gestational Age
Guinea Pigs
Hydatidiform Mole / blood
Immune Tolerance / physiology*
Peptides / blood*
Pregnancy Proteins*
Rosette Formation
Suppressor Factors, Immunologic*
Uterine Neoplasms / blood
Reg. No./Substance:
0/Chaperonin 10; 0/Peptides; 0/Pregnancy Proteins; 0/Suppressor Factors, Immunologic; 0/early pregnancy factor

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