Document Detail


The study of different solid forms of Emodepside.
MedLine Citation:
PMID:  18602468     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Emodepside is an endoparasiticide used in veterinary drugs. It exists in four different crystal forms which were characterised using DSC, TGA, evolved gas analysis (using FT-IR spectroscopy), hot-stage microscopy, FT-Raman, FT-IR and FT-NIR spectroscopy and powder X-ray diffraction. Thermal analysis showed that the forms II-IV contain considerable amounts of water being easily lost upon heating. Hot-stage microscopy indicated that the crystal structures do not change upon the loss of water. To examine whether the forms II-IV are hydrates or modifications of Emodepside having water adsorbed to the crystal surface and/or absorbed into disordered defect regions, the behaviour of the forms at different relative humidities was analysed using FT-Raman and FT-NIR spectroscopy and vapour sorption analysis. Changes in the C=O stretching region in the Raman spectra upon the removal of water revealed that all three forms represent non-stoichiometric hydrates forming isomorphic dehydrates. Sorption analysis indicated the presence of localised water molecules in the structure of form IV. Several OH combination bands of water were found in the NIR spectrum of each form indicating differently bound water molecules. Crystal structure analysis of form IV at ambient humidity revealed four well-defined water positions in the asymmetric unit.
Authors:
Julia Baronsky; Sabine Bongaerts; Michael Traeubel; Hans-Christoph Weiss; Nora Urbanetz
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Publication Detail:
Type:  Journal Article     Date:  2008-06-17
Journal Detail:
Title:  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V     Volume:  71     ISSN:  1873-3441     ISO Abbreviation:  Eur J Pharm Biopharm     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-16     Completed Date:  2009-04-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9109778     Medline TA:  Eur J Pharm Biopharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  88-99     Citation Subset:  IM    
Affiliation:
Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, Duesseldorf, Germany. julia.baronsky@bayerhealthcare.com
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MeSH Terms
Descriptor/Qualifier:
Anthelmintics / chemistry*
Calorimetry, Differential Scanning
Chemistry, Pharmaceutical / methods
Crystallization
Depsipeptides / chemistry*
Humidity
Microscopy / methods
Spectrum Analysis / methods
Temperature
Thermogravimetry
X-Ray Diffraction
Chemical
Reg. No./Substance:
0/Anthelmintics; 0/Depsipeptides; 0/emodepside

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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