Document Detail

A study of the cumulus-corona cell complex in in-vitro fertilization and embryo transfer; a prognostic indicator of the failure of implantation.
MedLine Citation:
PMID:  7962439     Owner:  NLM     Status:  MEDLINE    
In-vitro morphological changes and proliferation of cells of the cumulus oophorus, in particular cells of the corona radiata, were seen to differ between individuals and between oocytes of the same cohort in an unselected series of 159 IVF cycles. Cell proliferation did not relate to indications for treatment, type and length of ovarian stimulation, age of patient, ovarian response and quality of oocyte, fertilization rate or embryo morphology. A direct relationship, however, was demonstrated between the proliferative capacity of these cells and the incidence of clinical pregnancy. No pregnancies resulted when there was an absence of morphological change or proliferation of these cells. In cycles where the proliferative capacity of these cells varied between oocytes of a single cohort the pregnancy rate was 40% per cycle, and in cycles where cells associated with all oocytes underwent extensive proliferation the pregnancy rate was 49% (P < 0.001). Thus, regardless of the apparent quality of gametes or embryo, no pregnancies arose if the cumulus-corona complex was incapable of replication. We have, therefore, identified two populations of oocytes based on the proliferative capacity of cumulus-corona cells in vitro, one being associated with a failure of implantation.
L Gregory; A D Booth; C Wells; S M Walker
Related Documents :
10395229 - Evidence for an inverse relationship between apoptosis and inducible nitric oxide synth...
10732009 - Effects of cumulus cell density during in vitro maturation of the developmental compete...
9603249 - Differentiation of the corpus luteum of the mink (mustela vison): mitogenic and steroid...
17649829 - Stimulation of progesterone, estradiol and cortisol in trophoblast tumor bewo cells by ...
10446909 - Adenovirus-directed expression of a nonphosphorylatable mutant of creb (camp response e...
17535879 - The disruption of circadian clockwork in differentiating cells from rat reproductive ti...
22259119 - Fourier transform infrared microspectroscopy identifies protein propionylation in histo...
23724979 - Modifying dielectrophoretic response of nonviable yeast cells by ionic surfactant treat...
15659109 - Intracellular dopamine oxidation mediates rotenone-induced apoptosis in pc12 cells.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  9     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1994-12-16     Completed Date:  1994-12-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1308-17     Citation Subset:  IM    
Assisted Reproduction Unit, University Hospital of Wales, Heath Park, Cardiff, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blastocyst / cytology
Cell Division
Embryo Implantation
Embryo Transfer*
Fertilization in Vitro*
Infertility / pathology,  therapy
Oocytes / cytology*,  growth & development

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The secretion of gonadotrophin-releasing hormone by peri-implantation embryos of the rhesus monkey: ...
Next Document:  Monozygotic twinning in the human is associated with the zona pellucida architecture.