Document Detail

A study of culture positive multidrug resistant enteric fever--changing pattern and emerging resistance to ciprofloxacin.
MedLine Citation:
PMID:  7868549     Owner:  NLM     Status:  MEDLINE    
The present prospective study was carried out to observe the changing trends in the clinical pattern and multidrug resistance in typhoid fever. Fever was the main presenting feature. Other associated features were headache, vomiting, diarrhoea, altered sensorium and jaundice. Out of 78 patients, one patient died due to enteric encephalopathy and other due to septicaemia with peripheral circulatory failure. 12 patients responded to chloramphenicol and gentamycin. 51 patients responded to ciprofloxacin, while remaining 9 patients responded to combination of cefotaxime and amikacin. Three patients showed in vitro resistance to ciprofloxacin and two out of these also showed no response in vivo. This study re-emphasises the changing pattern, prolonged course and role of quinolones especially ciprofloxacin in the management of drug resistant typhoid fever, but at the same time indicates that ciprofloxacin is not the drug of choice in all cases of typhoid fever and resistance to it may be seen in some cases, where other drugs have to be used.
M K Daga; K Sarin; R Sarkar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of the Association of Physicians of India     Volume:  42     ISSN:  0004-5772     ISO Abbreviation:  J Assoc Physicians India     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1995-03-30     Completed Date:  1995-03-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505585     Medline TA:  J Assoc Physicians India     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  599-600     Citation Subset:  IM    
Dept of Medicine, Maulana Azad Medical College, New Delhi.
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MeSH Terms
Ciprofloxacin / therapeutic use*
Drug Resistance, Microbial
Prospective Studies
Typhoid Fever / diagnosis,  drug therapy*,  microbiology
Reg. No./Substance:

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