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A study comparing ocular pressure pulse and ocular fundus pulse in dependence of axial eye length and ocular volume.
MedLine Citation:
PMID:  20337602     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
PURPOSE: There is a long-standing discussion about whether myopia is associated with decreased choroidal blood flow, as suggested by pneumotonometric measurements of pulsatile ocular blood flow (POBF). However, it has been noted previously that calculations of POBF depend on intraocular volume.
METHODS: In the present study we investigated this volume dependence through the comparison of ocular pressure pulse and ocular fundus pulse. Fifty-one healthy participants with different refractive errors participated in the study. Pulse amplitude (PA) and POBF were measured using pneumotonometry. Fundus pulsation amplitude (FPA) was measured with laser interferometry. Axial eye length (AEL) was measured with partial coherence interferometry. A mathematical model was used to calculate choroidal volume changes based on FPA. The ocular pressure pulse was converted into pulse volume (PV) according to the standard procedure used for pneumotonometry.
RESULTS: PA and POBF were found to decrease with increasing axial length (r = -0.55, p < 0.001 and r = -0.57, p < 0.001, respectively). A similar relationship existed for PV (r = -0.57, p < 0.001) and FPA (r = -0.46, p = 0.001). In addition, there was a significant association between PV and choroidal volume change during the cardiac cycle (r = 0.61, p < 0.001).
CONCLUSION: The present study confirms experimentally that PA, FPA and POBF are dependent on ocular volume and indicates that the pulsatile component of ocular blood flow is not reduced in myopic patients. Accordingly, the relationship between AEL and POBF described previously appears to be a consequence of different ocular volumes. Our findings have important implications for studies using PA or POBF.
Authors:
Fatmire Berisha; Oliver Findl; Michael Lasta; Barbara Kiss; Leopold Schmetterer
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta ophthalmologica     Volume:  88     ISSN:  1755-3768     ISO Abbreviation:  Acta Ophthalmol     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101468102     Medline TA:  Acta Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  766-72     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. Journal compilation © 2010 Acta Ophthalmol.
Affiliation:
Department of Clinical Pharmacology, Medical University of Vienna, Austria.
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